Journal article
A Review and Rationale for the Use of Genetically Engineered Animals in the Study of Traumatic Brain Injury
Journal of cerebral blood flow and metabolism, v 21(11), pp 1241-1258
Nov 2001
PMID: 11702040
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and pathologic aspects of human head injury, and the development of genetically engineered animals has offered the opportunity to investigate the specific molecular and cellular mechanisms associated with cell dysfunction and death after TBI, allowing for the evaluation of specific cause-effect relations and mechanistic hypotheses. This article represents a compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases.
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Details
- Title
- A Review and Rationale for the Use of Genetically Engineered Animals in the Study of Traumatic Brain Injury
- Creators
- Luca Longhi - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.A., Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Ospedale Maggiore Policlinico IRCCS, Milan, ItalyKathryn E Saatman - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.ARamesh Raghupathi - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.AHelmut L Laurer - Department of Trauma Surgery, Johann Wolfgang Goethe-University, Frankfurt, GermanyPhilipp M Lenzlinger - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.APeter Riess - Department of Surgery, University of Cologne, Köln, GermanyEdmund Neugebauer - Department of Surgery, University of Cologne, Köln, GermanyJohn Q Trojanowski - Department of Pathology and Laboratory Medicine, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.AVirginia M.-Y Lee - Department of Pathology and Laboratory Medicine, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.AM. Sean Grady - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.ADavid I Graham - Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, U.KTracy K McIntosh - Department of Neurosurgery, University of Pennsylvania, and Veterans Administration Medical Center, Philadelphia, Pennsylvania, U.S.A
- Publication Details
- Journal of cerebral blood flow and metabolism, v 21(11), pp 1241-1258
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000172087000001
- Scopus ID
- 2-s2.0-0035203408
- Other Identifier
- 991014878444504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Hematology
- Neurosciences