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A Review of Translocation T(6;11) Renal Cell Carcinoma Tumors in the Adult Patient
Journal article   Open access   Peer reviewed

A Review of Translocation T(6;11) Renal Cell Carcinoma Tumors in the Adult Patient

Paulette Cutruzzula, David Cahn, Dana Kivlin, Carmen Tong, Daniel Edwards and Melanie Amster
Current urology, v 10(2), pp 69-71
30 May 2017
DOI: https://doi.org/10.1159/000447154
PMID: 28785190
url
https://doi.org/10.1159/000447154View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

MiT family translocation carcinomas Renal tumors Review t(6;11) RCC Translocation renal cell carcinoma Immunohistochemistry
Historically, T(6;11) renal cell carcinoma (RCC) has been associated with the pediatric and adolescent populations and documentation of this tumor in adults has been rare. However, the frequency of translocation renal cell carcinoma (TRCC) may be widely underestimated in the adult population due to an inadequate immunohistochemical workup or misdiagnosis from similar gross and histological findings to other RCC. A subset of MiT family translocation carcinomas, t(6:11) (p21;q12) translocation tumors cause an alpha-TFEB gene fusion. Morphologically, this neoplasm tends to mimic the various types of RCC's, including clear cell, papillary, and even epitheloid angiomyolipomas. Adult cases of TRCC have shown to behave more aggressively than their indolent pediatric counterpart, but due to the limited number of reported cases the true nature of these tumors has yet to be determined. The aim of this review is to bring an awareness of translocation RCC to better understand its diagnoses, treatment and prognosis, and, in turn, to allow for new cases to further highlight the behavior of this rare variant.

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