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Journal article
A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury
Frontiers in behavioral neuroscience, v 15, pp 601275-601275
04 Mar 2021
PMID: 33746719
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mild traumatic brain injury (TBI) results in chronic affective disorders such as depression, anxiety, and fear that persist up to years following injury and significantly impair the quality of life for patients. Although a great deal of research has contributed to defining symptoms of mild TBI, there are no adequate drug therapies for brain-injured individuals. Preclinical studies have modeled these deficits in affective behaviors post-injury to understand the underlying mechanisms with a view to developing appropriate treatment strategies. These studies have also unveiled sex differences that contribute to the varying phenotypes associated with each behavior. Although clinical and preclinical studies have viewed these behavioral deficits as separate entities with unique neurobiological mechanisms, mechanistic similarities suggest that a novel approach is needed to advance research on drug therapy. This review will discuss the circuitry involved in the expression of deficits in affective behaviors following mild TBI in humans and animals and provide evidence that the manifestation of impairment in these behaviors stems from an amygdala-dependent emotional processing deficit. It will highlight mechanistic similarities between these different types of affective behaviors that can potentially advance mild TBI drug therapy by investigating treatments for the deficits in affective behaviors as one entity, requiring the same treatment.
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Details
- Title
- A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury
- Creators
- Taylor A. McCorkle - Drexel UniversityJessica R. Barson - Drexel UniversityRamesh Raghupathi - Drexel University
- Publication Details
- Frontiers in behavioral neuroscience, v 15, pp 601275-601275
- Publisher
- Frontiers Media S.A
- Grant note
- National Institutes of Health Pennsylvania Department of Health National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000629973400001
- Scopus ID
- 2-s2.0-85102885476
- Other Identifier
- 991019169539804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences