Journal article
A SIMPLIFIED ALGORITHM FOR COMPUTING THE VARIATION IN OXYHEMOGLOBIN SATURATION WITH pH, PCO2, T AND DPG
Chemical engineering communications, v 47(1-3), pp 113-124
01 Sep 1986
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have modified a model for the oxyhemoglobin equilibrium curve (OHEC) and developed an algorithm for which the nonstandard OHEC can be computed. The model requires 2 parameters and a scaling factor (S
m
.) The model parameters are: P*, the oxygen partial pressure where the slope of the OHEC is at its maximum, and a rate parameter K. We estimated P* = 2.76 ± 0.04 SE kPa and K = 0.544 ±0.044 (SE) kPa
−1
from ten previous literature reports for the human OHEC at standard conditions (T = 37°C, pH = 7.4, PCO
2
= 5.33kPa and the molar concentration ratio [DPG7sol;Hb] = 0.9). We also determined how P* and K vary under nonstandard conditions by comparing the modified model with two previous nonstandard OHEC algorithms in the literature. These variations can be characterized by an additional 4 parameters. The dimensionless parameter product KP* was found to be relatively insensitive to deviations from standard conditions. We propose a new algorithm for the nonstandard OHEC which requires a total of 7 parameters, is simpler to implement and is computationally more efficient than other algorithms we investigated.
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Details
- Title
- A SIMPLIFIED ALGORITHM FOR COMPUTING THE VARIATION IN OXYHEMOGLOBIN SATURATION WITH pH, PCO2, T AND DPG
- Creators
- DONALD G. Buerk - Louisiana Tech UniversityERIC W. Bridges - Louisiana Tech University
- Publication Details
- Chemical engineering communications, v 47(1-3), pp 113-124
- Publisher
- Taylor and Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1986E331700007
- Scopus ID
- 2-s2.0-0342937884
- Other Identifier
- 991019231625304721
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- Web of Science research areas
- Engineering, Chemical