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Journal article
A Shorter Door-In-Door-Out Time Is Associated with Improved Outcome in Large Vessel Occlusion Stroke
The western journal of emergency medicine, v 24(5), pp 931-938
01 Sep 2023
PMID: 37788034
Abstract
Introduction: Endovascular thrombectomy (EVT) significantly improves outcomes in large vessel occlusion stroke (LVOS). When a patient with a LVOS arrives at a hospital that does not perform EVT, emergent transfer to an endovascular stroke center (ESC) is required. Our objective was to determine the association between door-in-door-out time (DIDO) and 90-day outcomes in patients undergoing EVT.
Methods: We conducted an analysis of the Optimizing Prehospital Stroke Systems of Care-Reacting to Changing Paradigms (OPUS-REACH) registry of 2,400 LVOS patients treated at nine ESCs in the United States. We examined the association between DIDO times and 90-day outcomes as measured by the modified Rankin scale.
Results: A total of 435 patients were included in the final analysis. The mean DIDO time for patients with good outcomes was 17 minute shorter than patients with poor outcomes (122 minutes [min] vs 139 min, P = 0.04). Absolute DIDO cutoff times of <= 60 min, <= 90 min, or <= 120 min were not associated with improved functional outcomes (46.4 vs 32.3%, P = 0.12; 38.6 vs 30.6%, P = 0.10; and 36.4 vs 28.9%, P = 0.10, respectively). This held true for patients with hyperacute strokes of less than four-hour onset. Lower baseline National Institutes of Health Stroke Scale (NIHSS) score (11.9 vs 18.2, P=<.001) and younger age (62.5 vs 74.9 years (P <.001) were associated with improved outcomes. On multiple regression analysis, age (odds ratio [OR] 1.71, 95% confidence interval [CI] 1.45-2.02) and baseline NIHSS score (OR 1.67, 95% CI 1.42-1.98) were associated with improved outcomes while DIDO time was not associated with better outcome (OR 1.13, 95% CI 0.99-1.30).
Conclusion: Although the DIDO time was shorter for patients with a good outcome, this was nonsignificant in multiple regression analysis. Receipt of intravenous thrombolysis and time to EVT were not associated with better outcomes, while male gender, lower age, arrival by private vehicle, and lower NIHSS score portended better outcomes. No absolute DIDO-time cutoff or modifiable factor was associated with improved outcomes for LVOS. This study underscores the need to streamline DIDO times but not to set an artificial DIDO time benchmark to meet.
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Details
- Title
- A Shorter Door-In-Door-Out Time Is Associated with Improved Outcome in Large Vessel Occlusion Stroke
- Creators
- Adam Sigal - Reading HospitalDerek L. Isenberg - Temple UniversityChadd K. Kraus - Geisinger Health SystemDaniel Ackerman - St. Luke's University Health NetworkJoseph Herres - Einstein Healthcare NetworkEthan S. Brandler - Stony Brook UniversityAlexander Kuc - Cooper University Health CareJason T. Nomura - Christiana Care Health SystemDerek R. Cooney - State University of New YorkMichael T. Mullen - Temple UniversityHuaqing Zhao - Temple UniversityNina T. Gentile - Temple University
- Publication Details
- The western journal of emergency medicine, v 24(5), pp 931-938
- Publisher
- eScholarship, University of California
- Number of pages
- 8
- Grant note
- American Heart Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:001155311100014
- Scopus ID
- 2-s2.0-85173039183
- Other Identifier
- 991022161423504721