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A Simple Combinatorial Experiment Based on Fischer Esterification. An Experiment Suitable for the First-Semester Organic Chemistry Lab
Journal article   Peer reviewed

A Simple Combinatorial Experiment Based on Fischer Esterification. An Experiment Suitable for the First-Semester Organic Chemistry Lab

Peter A. Wade, Susan A. Rutkowsky and Daniel B. King
Journal of chemical education, v 83(6), pp 927-928
Jun 2006

Abstract

A combinatorial experiment for the synthesis of esters by Fischer esterification is described. A total of eight esters are prepared as six mixtures. Deconvolution of the mixtures is performed by smell, the presence of methyl salicylate (wintergreen) being easily determined in the presence of other esters. Confirmation of the deconvolution results is obtained by GC analysis. Also demonstrated is the difference in Keq for the formation of different esters. The experiment is simple, chemicals are inexpensive, and one, three-hour lab period (or two, two-hour lab periods) is sufficient.

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Web of Science research areas
Chemistry, Multidisciplinary
Education, Scientific Disciplines
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