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Journal article
A Study on Dual-Response Composite Hydrogels Based on Oriented Nanocellulose
International Journal of Bioprinting, v 8(3), pp 578-578
10 Jun 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In nature, many biological tissues are composed of oriented structures, which endow tissues with special properties and functions. Although traditional hydrogels can achieve a high level of biomimetic composition, the orderly arrangement of internal structures remains a challenge. Therefore, it is of great significance to synthesize hydrogels with oriented structures easily and quickly. In this study, we first proposed and demonstrated a fabrication process for producing a well-ordered and dual-responsive cellulose nanofibers + hyaluronic acid methacrylate (CN+HAMA) hydrogels through an extrusion-based three-dimensional (3D) printing process. CN in the CN+HAMA hydrogels are directionally aligned after extrusion due to shear stress. In addition, the synthesized hydrogels exhibited responsive behaviors to both temperature and ultraviolet light. Since the temperature-responsiveness is reversible, the hydrogels can transit between the gelation and solution states while retaining their original qualities. Furthermore, the developed well-oriented CN+HAMA hydrogels induced directional cell growth, paving the way for potential applications in ordered biological soft-tissue repair.
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Details
- Title
- A Study on Dual-Response Composite Hydrogels Based on Oriented Nanocellulose
- Creators
- Lina DongMujiao LiangZhongwei GuoAnyang WangGangpei CaiTianying YuanShengli MiWei Sun
- Publication Details
- International Journal of Bioprinting, v 8(3), pp 578-578
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000836021900013
- Scopus ID
- 2-s2.0-85133030805
- Other Identifier
- 991019167464404721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials