Journal article
A Systematic A Priori Search for Candidate Genes Associated with the Exercise Blood Pressure Response
Medicine and science in sports and exercise, Vol.44(5S), pp.437-437
01 May 2012
Abstract
To develop a prioritized panel of candidate genetic variants that may have increased likelihood of associating with the BP response to exercise to be used in conjunction with genome wide association studies (GWAS). We searched for candidate genetic variants meeting preestablished criteria using PubMed and published systematic reviews. Meeting the inclusion criteria were: 1) 167 variants from 56 candidate genes within major BP regulatory pathways including the renal and renin angiotensin systems (114 variants, 32 genes), sympathetic nervous system (39 variants, 20 genes), and nitric oxide synthase pathway (14 variants, 4 genes); 2) 60 variants from GWAS meeting pre-established statistical criteria; 3) 68 variants on 25 candidate genes associated with energy metabolism and/or body composition; 4) 102 variants on 27 candidate genes associated with other CVD risk factors including lipids and lipoproteins (57 variants, 9 genes) and inflammatory, thrombotic, or haemostatic factors (45 variants, 18 genes); and 5) 129 variants from GWAS meeting nominal statistical significance after correction for multiple testing.
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Details
- Title
- A Systematic A Priori Search for Candidate Genes Associated with the Exercise Blood Pressure Response
- Creators
- Garrett AshAmanda AugeriJohn EicherMichael BruneauLinda Pescatello
- Publication Details
- Medicine and science in sports and exercise, Vol.44(5S), pp.437-437
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Identifiers
- 991020836476104721