Journal article
A VOLTAGE-SENSITIVE ULTRASOUND ENHANCING AGENT FOR MYOCARDIAL PERFUSION IMAGING IN A RAT MODEL
Ultrasound in medicine & biology, v 46(9), pp 2388-2399
01 Sep 2020
PMID: 32593498
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Echocardiographers with specialized expertise sometimes perform myocardial perfusion imaging using U.S. Food and Drug Administration-approved microbubbles in an off-label capacity, correlating microbub-ble replenishment in the near field with blood flow through the myocardium. This study reports the in vivo clini-cal feasibility of a voltage-sensitive ultrasound enhancing agent (UEA) for myocardial perfusion imaging. Four UEAs were injected into Sprague-Dawley rats while ultrasound images were collected to quantify brightness in the left ventricular (LV) cavity, septal wall, and posterior wall in systole and diastole. Formulation IV, a phase change agent nested within a negatively charged phospholipid bilayer, increased the tissue-to-cavity ratio in both systole and diastole in the septal wall, 6 dB, and in the posterior wall, 5 dB, while leaving the LV cavity at base-line. This outcome improves the signal of the myocardium relative to the LV cavity and shows promise as a myo-cardial perfusion UEA. (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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Details
- Title
- A VOLTAGE-SENSITIVE ULTRASOUND ENHANCING AGENT FOR MYOCARDIAL PERFUSION IMAGING IN A RAT MODEL
- Creators
- Michael Cimorelli - Drexel UniversityMichael A. Flynn - Drexel UniversityBrett Angel - Drexel UniversityEmily Reimold - Drexel UniversityAaron Fafarman - Drexel UniversityRichard Huneke - Drexel UniversityAndrew Kohut - University of PennsylvaniaSteven Wrenn - Drexel University
- Publication Details
- Ultrasound in medicine & biology, v 46(9), pp 2388-2399
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- 1829436 / National Science Foundation; National Science Foundation (NSF) Fulbright Open Research Award through the Netherlands-America Foundation P200 A150240 / Department of Education; US Department of Education Coulter-Drexel Translational Research Partnership Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Chemical and Biological Engineering
- Web of Science ID
- WOS:000558591200003
- Scopus ID
- 2-s2.0-85086940998
- Other Identifier
- 991019168886604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging