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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study
Cancer causes & control, v 19(10), pp 1201-1207
01 Dec 2008
PMID: 18560982
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A comprehensive case-control study was conducted to evaluate parental risk factors for medulloblastoma (MB) and primitive neuroectodermal tumor (PNET). This analysis was conducted to evaluate associations between fathers' hobbies and risk of their children developing MB/PNET. The hobbies chosen for study were those with similar exposures as occupations associated with childhood cancers.
Cases were 318 subjects under six years of age at diagnosis between 1991 and 1997 and registered with the Children's Cancer Group. An equal number of controls were selected through random digit dialing and individually matched to cases.
In multivariate analyses, a significant association was seen for lawn care with pesticides [during pregnancy: odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5; after birth: OR = 1.8, 95% CI: 1.2, 2.8] and a weak association was seen for stripping paint [during pregnancy: OR = 1.4, 95% CI: 0.8, 2.6; after birth: OR = 1.4, 95% CI: 0.7, 2.6].
This study suggests that household exposures from hobbies, particularly pesticides, may increase risk of MB/PNET in children; previous research has been mostly limited to occupational exposures.
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Details
- Title
- A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study
- Creators
- Andrea L. Rosso - Drexel UniversityMary E. Hovinga - Drexel UniversityLucy B. Rorke-Adams - Children's Hospital of PhiladelphiaLogan G. Spector - University of Minnesota Cancer CenterGreta R. Bunin - Children's Hospital of PhiladelphiaChildren's Oncology Group
- Publication Details
- Cancer causes & control, v 19(10), pp 1201-1207
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- R01 CA060951-04; U10 CA098543-06; U10 CA098543 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U10CA098543 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Biomedicine
- Web of Science ID
- WOS:000260766300020
- Scopus ID
- 2-s2.0-55849119895
- Other Identifier
- 991019168625204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health