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A case report of the neurocognitive and behavioral phenotype of mosaic trisomy 14
Journal article   Peer reviewed

A case report of the neurocognitive and behavioral phenotype of mosaic trisomy 14

Mary Godfrey, Manisha Udhnani and Nancy Raitano Lee
Neurocase, v 24(5-6), pp 250-254
02 Nov 2018
PMID: 30714851

Abstract

Cognition genetic disorder intellectual disability neurodevelopment
Mosaic trisomy 14 is associated with impaired intellectual functioning, although no study has examined the cognitive-behavioral profile associated with the syndrome. This study provides the first case description of the cognitive-behavioral phenotype associated with mosaic trisomy 14 by contrasting the performance an adolescent female (T14) with a group of females with Down syndrome (DS; n=9). T14 performed below age expectations on most direct assessments and demonstrated weaknesses relative to the DS group on aspects of language, adaptive functioning, and executive functioning. T14 also demonstrated strengths in delayed visual recall and social skills relative to the DS group.

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Web of Science research areas
Clinical Neurology
Psychiatry
Psychology
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