Journal article
A case study of applying text analysis to identify possible adverse drug interactions: The case of Adalat (Nifedipine)
Health informatics journal, v 26(2), pp 1455-1464
Jun 2020
PMID: 31635509
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adalat (Nifedipine) is a calcium-channel blocker that is also used as an antihypertensive drug. The drug was approved by the US Food and Drug Administration in 1985 but was discontinued in 1996 on account, among other things, of interactions with other medications. Nonetheless, Adalat is still used in other countries to treat congestive heart failure. We examine all the congestive heart failure electronic health records of the largest medical center in Israel to discover whether, possibly, taking Adalat with other medications is associated with patient death. This study examines a semantic space built by running latent semantic analysis on the entire corpus of congestive heart failure electronic health records of that medical center, encompassing 8 years of data on almost 12,000 patients. Through this semantic space, the most highly correlated medications and medical conditions that co-occurred with Adalat were identified. This was done separately for men and women. The results show that Adalat is correlated with different medications and conditions across genders. The data also suggest that taking Adalat with Captopril (angiotensin-converting enzyme inhibitor) or Rulid (antibiotic) might be dangerous in both genders. The study thus demonstrates the potential of applying latent semantic analysis to identify potentially dangerous drug interactions that may have otherwise gone under the radar.
Metrics
17 Record Views
Details
- Title
- A case study of applying text analysis to identify possible adverse drug interactions: The case of Adalat (Nifedipine)
- Creators
- David Gefen - Drexel University, USAOfir Ben-Assuli - Ono Academic College, IsraelNir Shlomo - Sheba Medical Centre, IsraelNoreen Robertson - Drexel University, USARobert Klempfner - Sheba Medical Centre, Israel
- Publication Details
- Health informatics journal, v 26(2), pp 1455-1464
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); SOM Dean - Research Administration
- Web of Science ID
- WOS:000491742300001
- Scopus ID
- 2-s2.0-85074438744
- Other Identifier
- 991014878281904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Health Care Sciences & Services
- Medical Informatics