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Journal article
A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
Current opinion in structural biology, v 20(1), pp 23-32
01 Feb 2010
PMID: 20053547
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The inherently error-prone nature of protein biosynthesis and turnover leads to a constant flux of destabilized proteins. Genetic mutations in conformational disease-associated proteins, as well as exposure to acute and chronic proteotoxic stresses, further increase the load of misfolded protein on the proteostasis network. During aging, this leads to enhanced instability of the proteome, failure to buffer destabilizing genetic mutations or polymorphisms, and cellular decline. The combination of cell-type-specific differences in the buffering capacity of the proteostasis network and destabilizing polymorphisms in the genetic background may account for some of the cell-type specificity observed in disease, even when the predominant disease-associated protein is widely expressed.
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Details
- Title
- A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
- Creators
- Tali Gidalevitz - Northwestern UniversityElise A. Kikis - Northwestern UniversityRichard I. Morimoto - Northwestern University
- Publication Details
- Current opinion in structural biology, v 20(1), pp 23-32
- Publisher
- Current Biology Ltd
- Number of pages
- 10
- Grant note
- HDSA Coalition R37GM038109 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01AG026647 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) National Institutes of Health (NINDS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institutes of Health (NIGMS and NIA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) ALS Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000275521000005
- Scopus ID
- 2-s2.0-77749319656
- Other Identifier
- 991020100089004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology