Journal article
A clinical and pathologic study of chronic sinusitis: The role of the eosinophil
Journal of allergy and clinical immunology, v 81(5), pp 867-875
1988
PMID: 3286721
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence exists that the eosinophil plays an important role in mediating injury to bronchial epithelium in chronic asthma. Here, the role of the eosinophil in chronic inflammatory disease of the paranasal sinuses was studied with tissue from patients who underwent surgery for chronic sinusitis. Paranasal tissue from patients with chronic asthma and/or allergic rhinitis was extensively infiltrated with eosinophils. Immunofluorescent studies demonstrated a striking association between the presence of extracellular deposition of major basic protein and damage to sinus mucosa. The histopathology of paranasal respiratory epithelium appeared similar to that described in bronchial asthma. These findings suggest that the eosinophil acts as an effector cell in chronic inflammatory disease of paranasal respiratory epithelium. Thus, sinus disease in patients with asthma may be due to the same mechanisms that cause damage to bronchial epithelium.
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Details
- Title
- A clinical and pathologic study of chronic sinusitis: The role of the eosinophil
- Creators
- Stephen L. Harlin - University of RochesterDavid G. Ansel - University of RochesterStanley R. Lane - University of RochesterJeffrey Myers - University of RochesterGail M. Kephart - University of RochesterGerald J. Gleich - University of Rochester
- Publication Details
- Journal of allergy and clinical immunology, v 81(5), pp 867-875
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:A1988N703600016
- Scopus ID
- 2-s2.0-0023901071
- Other Identifier
- 991019184184504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Allergy
- Immunology