Journal article
A clinical review of structural damage in psoriatic arthritis for dermatologists: From pathogenesis to ongoing controversies
Journal of the American Academy of Dermatology, v 90(2), pp 349-357
Feb 2024
PMID: 37852305
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory disease that often goes unrecognized in patients with psoriasis. As a result, patients may develop significant structural damage before diagnosis and initiation of adequate treatment. Dermatologists are in an unique position to identify early signs and symptoms of PsA. Here, we briefly review the pathogenesis of PsA, differences in PsA presentation within real-world dermatology practice versus rheumatology clinical trials, and imaging modalities that can be used to assess structural damage. We then discuss several ongoing controversies related to prediction, assessment, and treatment of PsA-related structural damage. Debated questions include the following: (1) Does subclinical enthesitis predict progression from psoriasis to PsA?, (2) Does methotrexate inhibit progression of structural damage?, (3) Does structural damage correlate with clinical disease activity?, and (4) Can progression from psoriasis to PsA be prevented? Evidence presented herein suggests that dermatologists, together with rheumatologists, can play important roles in the early diagnosis and treatment of PsA, thereby potentially preventing irreversible structural damage.
Metrics
Details
- Title
- A clinical review of structural damage in psoriatic arthritis for dermatologists: From pathogenesis to ongoing controversies
- Creators
- Joseph F. Merola - Brigham and Women's HospitalSoumya D. Chakravarty - Drexel UniversityOlivia Choi - JanssenDaphne Chan - JanssenAlice B. Gottlieb - Icahn School of Medicine at Mount Sinai
- Publication Details
- Journal of the American Academy of Dermatology, v 90(2), pp 349-357
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:001155850500001
- Scopus ID
- 2-s2.0-85176384760
- Other Identifier
- 991021930319304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Dermatology