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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
Environmental research, v 110(4), pp 388-395
2010
PMID: 20378105
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study.
The study population was 384 mother–infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age.
Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener.
At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age.
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Details
- Title
- A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age
- Creators
- Todd A. Jusko - University of WashingtonAnneclaire J. De Roos - Fred Hutchinson Cancer Research CenterStephen M. Schwartz - Fred Hutch Cancer CenterB. Paige Lawrence - University of RochesterLubica Palkovicova - Slovak Medical UniversityTomas Nemessanyi - Slovak Medical UniversityBeata Drobna - Slovak Medical UniversityAnna Fabisikova - Slovak Medical UniversityAnton Kocan - Slovak Medical UniversityDean Sonneborn - University of California, DavisEva Jahnova - Slovak Medical UniversityTerrance J. Kavanagh - University of WashingtonTomas Trnovec - Slovak Medical UniversityIrva Hertz-Picciotto - University of California, Davis
- Publication Details
- Environmental research, v 110(4), pp 388-395
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000277191700011
- Scopus ID
- 2-s2.0-77950951760
- Other Identifier
- 991020099364604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health