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Journal article
A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling
Proceedings of the National Academy of Sciences - PNAS, v 119(11), pp e2121180119-e2121180119
15 Mar 2022
PMID: 35254905
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
SignificanceIn a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of an
-produced genotoxin, colibactin, and its specific targeted killing of enteric pathogens and commensals, including
and
, sheds light on our understanding of intermicrobial interactions in the mammalian gut. Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes.
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Details
- Title
- A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling
- Creators
- Jiandong Chen - University of PennsylvaniaHyuntae Byun - University of PennsylvaniaRui Liu - University of California, RiversideI-Ji Jung - University of PennsylvaniaQinqin Pu - University of PennsylvaniaClara Y Zhu - Bryn Mawr CollegeEthan Tanchoco - University of California, RiversideSalma Alavi - University of California, RiversidePatrick H Degnan - University of California, RiversideAmy T Ma - Drexel UniversityManuela Roggiani - University of PennsylvaniaJoris Beld - Drexel UniversityMark Goulian - University of PennsylvaniaAnsel Hsiao - University of California, RiversideJun Zhu - University of Pennsylvania
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 119(11), pp e2121180119-e2121180119
- Publisher
- PNAS
- Grant note
- R35 GM124724 / NIGMS NIH HHS R01 AI157106 / NIAID NIH HHS R01 GM080279 / NIGMS NIH HHS R21 AI137283 / NIAID NIH HHS R01 AI120489 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000771756300010
- Scopus ID
- 2-s2.0-85125976705
- Other Identifier
- 991019169640204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology