Journal article
A common polymorphism in XRCC1 as a biomarker of susceptibility for chemically induced genetic damage
Biomarkers, v 8(5), pp 408-414
Oct 2003
PMID: 14602524
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have recently demonstrated a significant dose-response relationship between vinyl chloride exposure and mutant p53 biomarkers in humans. The aim of this study was to examine a common polymorphism in the DNA repair gene XRCC1 as a potential biomarker of susceptibility modifying this relationship, consistent with the known mechanism of production of p53 mutations via vinyl chloride-induced etheno-DNA adducts, which are repaired by XRCC1. A cohort of 211 French vinyl chloride workers were genotyped for the XRCC1 codon 399 polymorphism (CGG>CAG; Arg>Gln). Among the homozygous Arg-Arg individuals, 34% were biomarker positive compared with 47% in the heterozygous Arg-Gln individuals (adjusted odds ratio 1.73, 95% CI0.93-3.22) and 66% in the homozygous Gln-Gln individuals (adjusted odds ratio 3.95, 95% CI 1.68-9.28), with a significant trend for increasing Gln allele dosage (p=0.002). These preliminary results suggest that a common polymorphism in a DNA repair gene can be an important biomarker of susceptibility for chemically induced genetic damage.
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Details
- Title
- A common polymorphism in XRCC1 as a biomarker of susceptibility for chemically induced genetic damage
- Creators
- Yongliang Li - Columbia UniversityMarie-jeanne Marion - InsermAndrew Rundle - Columbia UniversityPaul W. Brandt-rauf - Columbia University
- Publication Details
- Biomarkers, v 8(5), pp 408-414
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000186343100005
- Scopus ID
- 2-s2.0-0345099236
- Other Identifier
- 991019323676504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Toxicology