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Journal article
A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice
Vaccine, v 29(38), pp 6505-6513
02 Sep 2011
PMID: 21767592
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Research into an efficacious Chlamydia trachomatis vaccine is ongoing, however, there has been no examination into the timing of vaccine administration to either asymptomatically or previously infected individuals. Using the female Chlamydia muridarum genital tract mouse model, we examined this aspect of vaccine development. Our results show timing of vaccination affected the production of systemic antibodies, but had minimal effects on mucosal antibody production. Vaccination during an active infection or after a resolved infection did not provide protection against re-exposure to Chlamydia, and did not exacerbate the development of pathological sequelae in infected mice. This demonstrates that vaccination may not be protective in individuals who are seropositive for an acute or previous chlamydial infection. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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Details
- Title
- A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice
- Creators
- Alison Carey - Queensland University of TechnologyKelly Cunningham - Queensland University of TechnologyDean Andrew - Queensland University of TechnologyLouise Hafner - Queensland University of TechnologyPeter Timms - Queensland University of TechnologyKenneth Beagley - Queensland University of Technology
- Publication Details
- Vaccine, v 29(38), pp 6505-6513
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Drexel University
- Web of Science ID
- WOS:000295148800014
- Scopus ID
- 2-s2.0-80051667802
- Other Identifier
- 991020099053804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental