Journal article
A computational model of nitric oxide production and transport in a parallel plate flow chamber
Annals of biomedical engineering, v 37(5), pp 943-954
May 2009
PMID: 19242805
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We developed a mathematical model to investigate the production and transport of nitric oxide (NO) generated by a monolayer of cultured endothelial cells exposed to flow in a parallel plate flow chamber. The objectives were to provide a theoretical framework for interpreting experimental observations and to suggest a quantitative relationship between shear stress and NO production rate. NO production was described as a combination of a basal production rate term and a shear-dependent term. Our results show that the shear stress-dependence of the production of NO by the endothelium influences the nature of mass transport within the boundary layer. We found that the steady state NO concentration near the endothelial surface exhibits a biphasic dependence on shear stress, in which at low flow, NO concentration decreases owing to the enhanced removal by convective transport while only at higher shear stresses does the increased production cause an increase in NO concentration. The unsteady response to step changes in flow exhibits transient fluctuations in NO that can be explained by time-dependent changes in the diffusive and convective mass transport as the concentration profile evolves. Our results indicate that this model can be used to determine the relationship between shear stress and NO production rate from measurements of NO concentration.
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Details
- Title
- A computational model of nitric oxide production and transport in a parallel plate flow chamber
- Creators
- A A Fadel - School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USAK A BarbeeD Jaron
- Publication Details
- Annals of biomedical engineering, v 37(5), pp 943-954
- Publisher
- Springer Nature; United States
- Grant note
- HL068164 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000264853800008
- Scopus ID
- 2-s2.0-63849344974
- Other Identifier
- 991014878147004721
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- Web of Science research areas
- Engineering, Biomedical