Journal article
A computational modeling approach for the characterization of mechanical properties of 3D alginate tissue scaffolds
Journal of applied biomaterials & biomechanics : JABB, v 6(1)
01 Jan 2008
PMID: 20740445
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Scaffold guided tissue engineering is an innovative approach wherein cells are seeded onto biocompatible and biodegradable materials to form 3-dimensional (3D) constructs that, when implanted in the body facilitate the regeneration of tissue. Tissue scaffolds act as artificial extracellular matrix providing the environment conducive for tissue growth. Characterization of scaffold properties is necessary to understand better the underlying processes involved in controlling cell behavior and formation of functional tissue. We report a computational modeling approach to characterize mechanical properties of 3D gel-like biomaterial, specifically, 3D alginate scaffold encapsulated with cells. Alginate inherent nonlinearity and variations arising from minute changes in its concentration and viscosity make experimental evaluation of its mechanical properties a challenging and time consuming task. We developed an in silico model to determine the stress-strain relationship of alginate based scaffolds from experimental data. In particular, we compared the Ogden hyperelastic model to other hyperelastic material models and determined that this model was the most suitable to characterize the nonlinear behavior of alginate. We further propose a mathematical model that represents the alginate material constants in Ogden model as a function of concentrations and viscosity. This study demonstrates the model capability to predict mechanical properties of 3D alginate scaffolds.
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Details
- Title
- A computational modeling approach for the characterization of mechanical properties of 3D alginate tissue scaffolds
- Creators
- K. Nair - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAK. C. Yan - Coll New Jersey, Ewing, NJ USAW. Sun - Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA
- Publication Details
- Journal of applied biomaterials & biomechanics : JABB, v 6(1)
- Publisher
- WICHTIG EDITORE
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000255727100006
- Other Identifier
- 991019167333704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical
- Materials Science, Biomaterials