A core outcome set for pre-eclampsia research: an international consensus development study

Jmn Duffy; A E Cairns; D Richards-Doran; J van 't Hooft; C Gale; M Brown; L C Chappell; W A Grobman; R Fitzpatrick; S A Karumanchi; A Khalil; D N Lucas; L A Magee; B W Mol; M Stark; S Thangaratinam; M J Wilson; P von Dadelszen; P R Williamson; S Ziebland; R J McManus; International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE); Vineet Bhandari

doi:10.1111/1471-0528.16319

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A core outcome set for pre-eclampsia research: an international consensus development study

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A core outcome set for pre-eclampsia research: an international consensus development study

Jmn Duffy, A E Cairns, D Richards-Doran, J van 't Hooft, C Gale, M Brown, L C Chappell, W A Grobman, R Fitzpatrick, S A Karumanchi, …

BJOG : an international journal of obstetrics and gynaecology, v 127(12), pp 1516-1526

Nov 2020

DOI: https://doi.org/10.1111/1471-0528.16319

PMID: 32416644

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Abstract

Biomedical Research

Female

Humans

International Cooperation

Pre-Eclampsia - therapy

Pregnancy

Pregnancy Outcome

To develop a core outcome set for pre-eclampsia. Consensus development study. International. Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Modified Delphi method and Modified Nominal Group Technique. A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].

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Title: A core outcome set for pre-eclampsia research: an international consensus development study
Creators: Jmn Duffy - University College London
A E Cairns - University College London
D Richards-Doran - University College London
J van 't Hooft - Department of Obstetrics and Gynaecology, Amsterdam UMC, Academic Medical Centre, Amsterdam, The Netherlands.
C Gale - Imperial College London
M Brown - UNSW Sydney
L C Chappell - King's College London
W A Grobman - Northwestern University
R Fitzpatrick - University of Oxford
S A Karumanchi - Cedars-Sinai Medical Center
A Khalil - St George's, University of London
D N Lucas - London North West Healthcare NHS Trust
L A Magee - King's College London
B W Mol - Monash University
M Stark - University of Adelaide
S Thangaratinam - Queen Mary University of London
M J Wilson - University of Sheffield
P von Dadelszen - King's College London
P R Williamson - University of Liverpool
S Ziebland - University College London
R J McManus - University College London
International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE)
Vineet Bhandari - Pediatrics
Publication Details: BJOG : an international journal of obstetrics and gynaecology, v 127(12), pp 1516-1526
Publisher: Wiley
Grant note: Barts Charity FS/15/32/31604 / British Heart Foundation NIHR-RP-02-12-015 / Department of Health RP-2014-05-019 / Department of Health MR/P027938/1 / Medical Research Council DRF-2014-07-051 / Department of Health National Institute for Health Research RP-PG-0614-20005 / Department of Health Elisabeth Garrett Anderson Hospital Charity Travelling Fellowship in Memory of Anne Boutwood
Resource Type: Journal article
Language: English
Academic Unit: Pediatrics
Web of Science ID: WOS:000541435900001
Scopus ID: 2-s2.0-85087149699
Other Identifier: 991019173419504721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Obstetrics & Gynecology

A core outcome set for pre-eclampsia research: an international consensus development study

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UN Sustainable Development Goals (SDGs)

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