A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

Stuart S MARTIN; Alan G RIDGEWAY; Jan PINKAS; Y U YU LU; Mauricio J REGINATO; Eugene Y KOH; Montserrat MICHELMAN; George Q DALEY; Joan S BRUGGE; Philip LEDER

doi:10.1038/sj.onc.1207595

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A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

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A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

Stuart S MARTIN, Alan G RIDGEWAY, Jan PINKAS, Y U YU LU, Mauricio J REGINATO, Eugene Y KOH, Montserrat MICHELMAN, George Q DALEY, Joan S BRUGGE and Philip LEDER

Oncogene, v 23(26), pp 4641-4645

2004

DOI: https://doi.org/10.1038/sj.onc.1207595

PMID: 15064711

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Abstract

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Cell physiology

Molecular and cellular biology

Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes

Ageing, cell death

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58 citations in Web of Science

64 citations in Scopus

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Title: A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth
Creators: Stuart S MARTIN - Harvard Medical School, Department of Genetics, Howard Hughes Medical Institute, Boston, MA 02115, United States
Alan G RIDGEWAY - Harvard Medical School, Department of Genetics, Howard Hughes Medical Institute, Boston, MA 02115, United States
Jan PINKAS - Genzyme Corporation, Framingham, MA 01701, United States
Y U YU LU - Harvard Medical School, Department of Cell Biology, Boston, MA 02115, United States
Mauricio J REGINATO - Harvard Medical School, Department of Cell Biology, Boston, MA 02115, United States
Eugene Y KOH - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, United States
Montserrat MICHELMAN - Harvard Medical School, Department of Genetics, Howard Hughes Medical Institute, Boston, MA 02115, United States
George Q DALEY - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, United States
Joan S BRUGGE - Harvard Medical School, Department of Cell Biology, Boston, MA 02115, United States
Philip LEDER - Harvard Medical School, Department of Genetics, Howard Hughes Medical Institute, Boston, MA 02115, United States
Publication Details: Oncogene, v 23(26), pp 4641-4645
Publisher: Nature Publishing; Basingstoke
Resource Type: Journal article
Language: English
Academic Unit: Biochemistry and Molecular Biology
Web of Science ID: WOS:000221799000014
Scopus ID: 2-s2.0-3042623408
Other Identifier: 991014878022904721

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Collaboration types: Industry collaboration; Domestic collaboration
Web of Science research areas: Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity; Oncology

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

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