Journal article
A defined locus control region determinant links chromatin domain acetylation with long-range gene activation
Molecular cell, v 9(2), pp 291-302
Feb 2002
PMID: 11864603
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gene activation in higher eukaryotes is often under the control of regulatory elements quite distant from their target promoters. It is unclear how such long-range control is mediated. Here we show that a single determinant of the human growth hormone locus control region (hGH LCR) located 14.5 kb 5prime prime or minute to the hGH-N promoter has a critical, specific, and nonredundant role in facilitating promoter trans factor binding and activating hGH-N transcription. Significantly, this same determinant plays an essential role in establishing a 32 kb acetylated domain that encompasses the entire hGH LCR and the contiguous hGH-N promoter. These data support a model for long-range gene activation via LCR-mediated targeting and extensive spreading of core histone acetylation.
Metrics
Details
- Title
- A defined locus control region determinant links chromatin domain acetylation with long-range gene activation
- Creators
- Yugong Ho - Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USAFelice ElefantNancy CookeStephen Liebhaber
- Publication Details
- Molecular cell, v 9(2), pp 291-302
- Publisher
- Elsevier; United States
- Grant note
- F32-DK-10051 / NIDDK NIH HHS HD25147 / NICHD NIH HHS F32-HD-08471 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000173927000013
- Scopus ID
- 2-s2.0-0036187459
- Other Identifier
- 991014878221704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology