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Journal article
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
Communications biology, v 4(1), pp 563-563
12 May 2021
PMID: 33980982
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Innate Lymphoid Cells (ILCs) are immune cells typically found on mucosal surfaces and in secondary lymphoid organs where they regulate the immune response to pathogens. Despite their key role in the immune response, there are still fundamental gaps in our understanding of ILCs. Here we report a human ILC population present in the follicles of tonsils and lymph nodes termed follicular regulatory ILCs (ILC
) that to our knowledge has not been previously identified. ILC
have a distinct phenotype and transcriptional program when compared to other defined ILCs. Surprisingly, ILC
inhibit the ability of follicular helper T (Tfh) cells to provide B cell help. The localization of ILC
to the germinal centers suggests these cells may interfere with germinal center B cell (GC-B) and germinal center Tfh cell (GC-Tfh) interactions through the production of transforming growth factor beta (TGF-β. Intriguingly, under conditions of impaired GC-Tfh-GC-B cell interactions, such as human immunodeficiency virus (HIV) infection, the frequency of these cells is increased. Overall, we predict a role for ILC
in regulating GC-Tfh-GC-B cell interactions and propose they expand in chronic inflammatory conditions.
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Details
- Title
- A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
- Creators
- Margaret H O'Connor - Drexel UniversityRoshell Muir - Drexel UniversityMarita Chakhtoura - Drexel UniversityMichael Fang - The Department of Population and Quantitative Health Services, Case Western Reserve University, Cleveland, OH, USAEirini Moysi - Vaccine Research CenterSusan Moir - National Institute of Allergy and Infectious DiseasesAlison J Carey - Drexel UniversityAlyssa Terk - St. Christopher's Hospital for ChildrenCarmen N Nichols - Case Western Reserve UniversityTalibah Metcalf - Drexel UniversityConstantinos Petrovas - Vaccine Research CenterMark J Cameron - Case Western Reserve UniversityVirginie Tardif - University of RouenElias K Haddad - Drexel University
- Publication Details
- Communications biology, v 4(1), pp 563-563
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Pediatrics; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000656275200004
- Scopus ID
- 2-s2.0-85105793809
- Other Identifier
- 991019167734904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology