Journal article
A follow-up study of synthetic rubber workers
Toxicology (Amsterdam), v 113(1), pp 182-189
1996
PMID: 8901897
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although 1,3-butadiene (BD) has been classified as an animal carcinogen, epidemiologic research has reported inconsistent results on the relationship between BD and lymphopoietic and other cancers in humans. This study evaluated the mortality experience of 15649 men employed for at least 1 year at any of eight North American styrene-butadiene rubber (SBR) plants. About 75% of the subjects were exposed to BD; 83% were exposed to styrene (STY). During 1943–1991, the cohort had a total of 386 172 and an average of 25 person-years of follow-up, with 3976 deaths observed compared to 4553 deaths expected based on general population mortality rates (standardized mortality ratio (SMR) = 87, 95% confidence interval (CI) = 85–90). More than expected leukemia deaths occurred in the overall cohort (
48
observed
37
expected, SMR = 131,
CI = 97–174
) and among ever hourly subjects (
45
32
,
SMR = 143,
CI = 104–191
). The excess was concentrated among ever hourly subjects with 10 + years worked and 20+ years since hire (
28
13
,
SMR = 224,
CI = 149–323
) and among subjects in polymerization (
15
6.0
,
SMR = 251,
CI = 140–414
), maintenance labor (
13
4.9
,
SMR = 265,
CI = 141–453
) and laboratories (
10
2.3
,
SMR = 431,
CI = 207–793
), three areas with potential for relatively high exposure to BD or STY monomers. Some cohort sub-groups had slight increases in deaths from lymphopoietic cancers other than leukemia, but mortality patterns by race, years worked and process group within the SBR industry did not indicate a causal association with occupational exposures. These results indicate that exposures in the SBR industry cause leukemia.
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Details
- Title
- A follow-up study of synthetic rubber workers
- Creators
- Elizabeth Delzell - Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USANalini Sathiakumar - Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USAMary Hovinga - Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USAMaurizio Macaluso - Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USAJim Julian - Occupational Health Program, McMaster University, Hamilton, Ontario, CanadaRodney Larson - Department of Environmental Engineering, Texas A&M University, Kingsville, Texas, USAPhilip Cole - Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USADavid C.F Muir - Occupational Health Program, McMaster University, Hamilton, Ontario, Canada
- Publication Details
- Toxicology (Amsterdam), v 113(1), pp 182-189
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:A1996VQ39100026
- Scopus ID
- 2-s2.0-0030605080
- Other Identifier
- 991014878041804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology