Journal article
A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis
Molecular and biochemical parasitology, Vol.69(1)
1995
PMID: 7723789
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Infection of mosquitoes by
Plasmodium spp. requires sexual differentiation of the malarial parasite in the vertebrate host and mating of the heterogametes in the vector midgut. A
Plasmodium falciparum clone, Dd2, differentiates into normal-appearing gametocytes, yet poorly infects mosquitoes. The Dd2 clone, however, effectively cross-fertilized HB3, a Central American
P. falciparum clone, and yielded several independent recombinant progeny. We have examined 11 HB3 × Dd2 progeny for their ability to infect mosquitoes and to differentiate into male gametes. Our analyses indicate that the poor mosquito-infectivity of the Dd2 clone results from a defect in male gametogenesis. This defect was inherited as a single locus in the independent recombinant progeny of HB3 × Dd2. Comparison with a restriction fragment length polymorphism map of the HB3 × Dd2 cross indicates that the defective phenotype of Dd2 maps to a locus on
P. falciparum chromosome 12. This genetic locus may contain determinants that play a crucial role in male gametogenesis by
P. falciparum.
Metrics
8 Record Views
Details
- Title
- A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis
- Creators
- Akhil B Vaidya - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USAOlga Muratova - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USAFrançoise Guinet - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USADavid Keister - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USAThomas E Wellems - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USADavid C Kaslow - Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Philadelphia, PA, USA
- Publication Details
- Molecular and biochemical parasitology, Vol.69(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991014878176204721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Parasitology