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Journal article
A genetic variant in IL-15Rα correlates with physical activity among European-American adults
Molecular genetics & genomic medicine, v 6(3), pp 401-408
May 2018
PMID: 29624921
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults.
Methods
Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2) and women (n = 292, 23.2 ± 0.3 year, 24.0 ± 0.3 kg/m2) were genotyped. Physical activity phenotypes were derived from the Paffenbarger Physical Activity Questionnaire. Analysis of covariance (ancova) tested log-transformed differences between the IL-15Rα genotype and physical activity phenotypes by gender with age and BMI as covariates.
Results
Men with the IL-15Rα 1775AA genotype spent more time in light intensity physical activity (39.4 ± 2.4 hr/week) than men with the CC genotype (28.6 ± 2.3 hr/week, (p = .009).
Conclusion
Further research is needed to confirm our finding and determine the possible mechanisms by which the IL-15Rα variant modulates light intensity physical activity.
Metrics
Details
- Title
- A genetic variant in IL-15Rα correlates with physical activity among European-American adults
- Creators
- Michael Bruneau, Jr - Drexel UniversitySean Walsh - Central Connecticut State UniversityEric Selinsky - University of ConnecticutGarrett Ash - Yale UniversityTheodore J Angelopoulos - Emory and Henry CollegePriscilla Clarkson - University of Massachusetts AmherstPaul Gordon - Baylor UniversityNiall Moyna - Dublin City UniversityPaul Visich - University of New EnglandRobert Zoeller - Florida Atlantic UniversityPaul Thompson - Hartford HospitalHeather Gordish-Dressman - Children's NationalEric Hoffman - Cooperative International Neuromuscular Research Group, Washington, DC, USA.Joseph Devaney - Children’s National Health SystemLinda S Pescatello - University of Connecticut
- Publication Details
- Molecular genetics & genomic medicine, v 6(3), pp 401-408
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- T32 DK097718 / NIDDK NIH HHS R01 NS040606 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:000435947300011
- Scopus ID
- 2-s2.0-85044921554
- Other Identifier
- 991019168280004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity