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Journal article
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Nature communications, v 6(1), pp 5751-5751
08 Jan 2015
PMID: 25569183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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- Title
- A genome-wide association study of marginal zone lymphoma shows association to the HLA region
- Creators
- Joseph Vijai - Memorial Sloan Kettering Cancer CenterZhaoming Wang - National Institutes of HealthSonja I Berndt - National Institutes of HealthChristine F Skibola - University of California, BerkeleySusan L Slager - Mayo ClinicSilvia de Sanjose - 1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, SpainMads Melbye - Stanford UniversityBengt Glimelius - Karolinska InstitutePaige M Bracci - University of California, San FranciscoLucia Conde - University of California, BerkeleyBrenda M Birmann - Harvard UniversitySophia S Wang - City Of Hope National Medical CenterAngela R Brooks-Wilson - Simon Fraser UniversityQing Lan - National Institutes of HealthPaul I W de Bakker - Utrecht UniversityRoel C H Vermeulen - 1] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The NetherlandsCarol Portlock - Memorial Sloan Kettering Cancer CenterStephen M Ansell - Mayo ClinicBrian K Link - University of IowaJacques Riby - University of California, BerkeleyKari E North - University of North Carolina at Chapel HillJian Gu - The University of Texas MD Anderson Cancer CenterHenrik Hjalgrim - Statens Serum InstitutWendy Cozen - University of Southern CaliforniaNikolaus Becker - German Cancer Research CenterLauren R Teras - American Cancer SocietyJohn J Spinelli - University of British ColumbiaJenny Turner - Macquarie UniversityYawei Zhang - Yale UniversityMark P Purdue - National Institutes of HealthGraham G Giles - University of MelbourneRachel S Kelly - Imperial College LondonAnne Zeleniuch-Jacquotte - New York UniversityMaria Grazia Ennas - University of CagliariAlain Monnereau - 1] Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif F-94807, France UMRS 1018, Univ Paris Sud, Villejuif F-94807, France Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux 33076, FranceKimberly A Bertrand - Harvard UniversityDemetrius Albanes - National Institutes of HealthTracy Lightfoot - University of YorkMeredith Yeager - National Institutes of HealthCharles C Chung - National Institutes of HealthLaurie Burdett - National Institutes of HealthAmy Hutchinson - National Institutes of HealthCharles Lawrence - Health Studies Sector, Westat, Rockville, Maryland 20850, USARebecca Montalvan - Health Studies Sector, Westat, Rockville, Maryland 20850, USALiming Liang - Harvard UniversityJinyan Huang - Harvard UniversityBaoshan Ma - Dalian Maritime UniversityDanylo J Villano - Memorial Sloan Kettering Cancer CenterAnn Maria - Memorial Sloan Kettering Cancer CenterMarina Corines - Memorial Sloan Kettering Cancer CenterTinu Thomas - Memorial Sloan Kettering Cancer CenterAnne J Novak - Mayo ClinicAhmet Dogan - Memorial Sloan Kettering Cancer CenterMark Liebow - Mayo ClinicCarrie A Thompson - Mayo ClinicThomas E Witzig - Mayo ClinicThomas M Habermann - Mayo ClinicGeorge J Weiner - University of IowaMartyn T Smith - University of California, BerkeleyElizabeth A Holly - University of California, San FranciscoRebecca D Jackson - The Ohio State UniversityLesley F Tinker - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaYuanqing Ye - The University of Texas MD Anderson Cancer CenterHans-Olov Adami - Karolinska InstituteKarin E Smedby - Karolinska InstituteAnneclaire J De Roos - Drexel UniversityPatricia Hartge - National Institutes of HealthLindsay M Morton - National Institutes of HealthRichard K Severson - Wayne State UniversityYolanda Benavente - 1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, SpainPaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - International Agency For Research On CancerLenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 65653, Czech RepublicMarc Maynadie - University of BurgundyJames McKay - International Agency For Research On CancerAnthony Staines - Dublin City UniversityW Ryan Diver - American Cancer SocietyClaire M Vajdic - UNSW SydneyBruce K Armstrong - University of SydneyAnne Kricker - University of SydneyTongzhang Zheng - Yale UniversityTheodore R Holford - Yale UniversityGianluca Severi - University of MelbournePaolo Vineis - Imperial College LondonGiovanni M Ferri - University of Bari Aldo MoroRosalia Ricco - University of Bari Aldo MoroLucia Miligi - Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, ItalyJacqueline Clavel - 1] Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif F-94807, France UMRS 1018, Univ Paris Sud, Villejuif F-94807, FranceEdward Giovannucci - Harvard UniversityPeter Kraft - Harvard UniversityJarmo Virtamo - Finnish Institute for Health and WelfareAlex Smith - University of YorkEleanor Kane - University of YorkEve Roman - University of YorkBrian C H Chiu - University of ChicagoJoseph F Fraumeni - National Institutes of HealthXifeng Wu - The University of Texas MD Anderson Cancer CenterJames R Cerhan - Mayo ClinicKenneth Offit - Memorial Sloan Kettering Cancer CenterStephen J Chanock - National Institutes of HealthNathaniel Rothman - National Institutes of HealthAlexandra Nieters - University of Freiburg
- Publication Details
- Nature communications, v 6(1), pp 5751-5751
- Publisher
- Springer Nature
- Grant note
- R01 CA092153 / NCI NIH HHS UL1 TR000142 / NCATS NIH HHS U58 DP000807 / NCCDPHP CDC HHS R01 CA154643 / NCI NIH HHS HHSN268201100004I / NHLBI NIH HHS CA87969 / NCI NIH HHS R01 CA062006 / NCI NIH HHS ES000260 / NIEHS NIH HHS U01 CA049449 / NCI NIH HHS HHSN268201100004C / WHI NIH HHS R01 CA098122 / NCI NIH HHS Intramural NIH HHS HHSN268201100002C / WHI NIH HHS HHSN261201000035C / NCI NIH HHS N01-PC-67009 / NCI NIH HHS N01CO12400 / NCI NIH HHS HHSN268201100003C / WHI NIH HHS P50 CA97274 / NCI NIH HHS R21 CA178800 / NCI NIH HHS P30 ES000260 / NIEHS NIH HHS N02-PC-71105 / NCI NIH HHS UL1 TR000135 / NCATS NIH HHS R01CA1046282 / NCI NIH HHS P01 CA087969 / NCI NIH HHS CA098122 / NCI NIH HHS HHSN268201100046C / NHLBI NIH HHS R25 CA098566 / NCI NIH HHS P30 CA016359 / NCI NIH HHS CA49449 / NCI NIH HHS 5R01 CA69669-02 / NCI NIH HHS HHSN261201000035I / NCI NIH HHS CA098566 / NCI NIH HHS HHSN271201100004C / NIA NIH HHS U01 HG007033 / NHGRI NIH HHS P30 CA033572 / NCI NIH HHS CA97274 / NCI NIH HHS N01 PC067008 / NCI NIH HHS N01 PC065064 / NCI NIH HHS P30 CA015083 / NCI NIH HHS P50 CA097274 / NCI NIH HHS CA149445 / NCI NIH HHS HHSN268201100003I / NHLBI NIH HHS P30 CA016672 / NCI NIH HHS HHSN261201000140C / NCI NIH HHS R01 CA129539 / NCI NIH HHS #1U58 DP000807-01 / NCCDPHP CDC HHS N01-RC-45035 / CCR NIH HHS U01 CA167552 / NCI NIH HHS UM1 CA167552 / NCI NIH HHS R01 CA098661 / NCI NIH HHS HHSN268201100002I / NHLBI NIH HHS N01 PC067010 / NCI NIH HHS HHSN268201100001C / WHI NIH HHS R01CA154643 / NCI NIH HHS CIHR UM1 CA182934 / NCI NIH HHS HHSN261201000034C / NCI NIH HHS N01 CN045165 / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS P30 CA008748 / NCI NIH HHS CA167552 / NCI NIH HHS K07 CA115687 / NCI NIH HHS R01 CA149445 / NCI NIH HHS HHSN268201100001I / NHLBI NIH HHS R01 CA049449 / NCI NIH HHS N01RC37004 / CCR NIH HHS P30 CA016087 / NCI NIH HHS N01 PC067009 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000348646500001
- Scopus ID
- 2-s2.0-84929662642
- Other Identifier
- 991019168490104721
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