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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
A global action agenda for turning the tide on fatty liver disease
Heptalogy, v 79(2), pp 502-523
2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Aims:
Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care.
Approach and Results:
We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of “agree” responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% “agree”). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance.
Conclusions:
This consensus-driven multidisciplinary fatty liver disease action agenda developed by care providers, clinical researchers, and public health and policy experts provides a path to reduce the prevalence of fatty liver disease and improve health outcomes. To implement this agenda, concerted efforts will be needed at the global, regional, and national levels.
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Details
- Title
- A global action agenda for turning the tide on fatty liver disease
- Creators
- Jeffrey V LazarusHenry E MarkAlina M AllenJuan Pablo ArabPatrizia CarrieriMazen NoureddinWilliam AlazawiNaim AlkhouriSaleh A AlqahtaniQuentin M AnsteeMarco ArreseRamon BatallerThomas BergPaul N BrennanPatrizia BurraGraciela E Castro-NarroHelena Cortez-PintoKenneth CusiNikos DedesAjay DusejaSven M FrancqueAmalia GastaldelliHannes HagströmTerry T.-K HuangDana Ivancovsky WajcmanAchim KautzChristopher J KopkaAleksander KragPhilip N NewsomeMary E RinellaDiana RomeroShiv Kumar SarinMarcelo SilvaC. Wendy SpearmanNorah A TerraultEmmanuel A TsochatzisLuca ValentiMarcela Villota-RivasShira Zelber-SagiJörn M SchattenbergVincent Wai-Sun WongZobair M YounossiFredrik AbergLeon A AdamsKhalid Al-NaamaniReda M AlbadawyZinaida AlexaMichael AllisonFaisal Abdullatif AlnaserKhalid AlswatMario R Alvares-Da-SilvaDomenico AlvaroMichele Alves-BezerraRaul J AndradeYaw Asante AwukuOidov BaatarkhuuGyorgy BaffyShokhista R BakievaMeena B BansalRobert BaroukiRachel L BatterhamCynthia BehlingRenata Belfort-DeAguiarAnnalisa BerzigottiMichael BetelCristiana BiancoEmanuele BosiJerome BoursierElizabeth M BruntElisabetta BugianesiChristopher J ByrneMaria Cecilia Cabrera CabrejosStephen CaldwellRotonya CarrMarlen Ivón Castellanos FernándezLaurent CasteraMaria Gabriela Castillo-LópezCyrielle CaussyEira Cerda-ReyesAntonio CerielloWah-Kheong ChanYoosoo ChangPhunchai CharatcharoenwitthayaNorberto Chavez-TapiaRaymond T ChungMassimo ColomboKirsten J CoppellHelma P CotrimAntonio CraxiJavier CrespoAnuradha DassanayakeNicholas O DavidsonRobert J de KnegtVictor de LedinghenMünevver DemirHailemichael DesalegnMoises DiagoJohn F DillonBruce DimmigM. Ashworth DiracMelisa DirchwolfJean-François DufourKarel DvorakMattias EkstedtMohamed El-KassasOsama M ElsanousiAhmed M ElsharkawyReda M ElwakilWayne EskridgeMohammed EslamGamal EsmatJian-Gao FanMaria Lucia FerrazRobert FlisiakDavide FortinYasser FouadScott L FriedmanMichael FuchsAdrian GadanoAnja GeertsAndreas GeierJacob GeorgeLynn H GerberHasmik L GhazinyanLiana GheorgheDenise Giangola KileMarcos GiralaGeorge Goh Boon BeeNicolas GoossensIsabel GrauperaHenning GrønbækSaeed HamidVanessa HebditchZachary HenryIngrid J HickmanL. Ansley HobbsSamantha L HockingWolf Peter HofmannRamazan IdilmanPaula IruzubietaScott IsaacsVasily A IsakovMona H IsmailMohammad H JamalHelen JarvisPeter JepsenFrançois R JornayvazK.C SudhamshuSatoru KakizakiSaul KarpenTakumi KawaguchiShelley E KeatingYousef KhaderSeung Up KimWon KimDavid E KleinerGer KoekNarcisse Patrice Joseph KomasLoreta A KondiliBart G KootMarko KorenjakEleni KotsilitiYiannoula KoullaCarina KugelmasMarcelo KugelmasAsma LabidiNaomi F LangeMariana LazoNathalie LeiteHan-Chieh LinUndram LkhagvaaMichelle T LongPatricio Lopez-JaramilloAdelina LozanoMaria Paula MacedoReza MalekzadehGiulio MarchesiniSebastian MarcianoKim MartinezSophia E Martínez VázquezLyudmila MatevaJosé M MatoCharles N MbendiAlexis Gorden McCaryJeff McIntyreMartin McKeeJuan M MendiveIvana MikolasevicPamela S MillerTamara MilovanovicTerri MiltonRosalba Moreno-AlcantarTimothy R MorganAyesha A MotalaJean MurisCarla MussoEdna J Nava-GonzálezFrancesco NegroAlexander V NersesovBrent A Neuschwander-TetriDafina NikolovaSuzanne NorrisKatja NovakPonsiano OcamaJanus P OngArlinking Ong-GoCharles OnyekwereP. Martin Padilla-MachacaRaluca PaisCalvin Q PanArturo PanduroManas K PanigrahiGeorgios PapatheodoridisImran ParukKeyur PatelCarlos Penha-GoncalvesNorma M PérezJuanita Pérez-EscobarJuan M PericàsGianluca PerseghinMário Guimarães PessoaSalvatore PettaClaudia Pinto Marques Souza de OliveiraDorairaj PrabhakaranRachel PrykeNikolaos PyrsopoulosAtoosa RabieeAlnoor RamjiVlad RatziuNatarajan RavendhranKatrina RayMichael RodenStefano RomeoManuel Romero-GómezYaron RotmanSamir RouabhiaIan A RoweShakhlo SadirovaMaryam Salem AlkhatryRiina SalupereSanjaya K SatapathyJeffrey B SchwimmerGiada SebastianiLynn SeimYosuke SekiAbdel Karim SermeDavid ShapiroLali SharvadzeJonathan E ShawIsaac Thom ShawaThrivikrama ShenoyOren ShiboletYusuke ShimakawaJay H ShubrookShivaram Prasad SinghEdford SinkalaLubomir SkladanyIgor SkrypnykMyeong Jun SongSilvia SookoianJoan B SorianoKannan SridharanNorbert StefanJonathan G StineNikos StratakisDhastagir Sultan SheriffShikha S SundaramGianluca Svegliati-BaroniMark G SwainFrank TackeShahrad TaheriSoek-Siam TanElliot B TapperGiovanni TargherEugen TcaciucMaja ThieleDina TiniakosIeva TolmaneAldo TorreEsther A TorresSombat TreeprasertsukMichael TrenellSvetlana TurcanAdela TurcanuJonas ValantinasLaurens A van KleefJose Antonio Velarde Ruiz VelascoMette Nåmdal VesterhusEduardo Vilar-GomezImam WakedJulia WattacherilHeiner WedemeyerFonda WilkinsJosé WillemseRobert J WongYusuf YilmazHannele Yki-JärvinenMing-Lung YuVolkan YumukMüjdat ZeybelKenneth I ZhengMing-Hua Zheng
- Publication Details
- Heptalogy, v 79(2), pp 502-523
- Publisher
- Wolters Kluwer
- Number of pages
- 22
- Grant note
The data collection and analysis were funded by the European Association for the Study of the Liver (EASL), with support from Takeda, MSD, Bristol-Myers-Squibb Company, and Apollo Endo.r Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, Jorn M. Schattenberg, Vincent Wai-Sun Wong, and Zobair M. Younossi contributed equally.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Community Health and Prevention
- Web of Science ID
- WOS:001072428600001
- Scopus ID
- 2-s2.0-85169126126
- Other Identifier
- 991021896915004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology