Journal article
A guest-host hydrogel for neural tissue engineering applications
Journal of materials chemistry. B, Materials for biology and medicine, Forthcoming
15 Jun 2026
PMID: 42300853
Abstract
Worldwide, neurological injuries and disorders are a leading cause of disability, yet there are limited treatment options that address the underlying mechanisms associated with these injuries and diseases. Injectable hydrogels may serve as a neural tissue engineering platform to promote tissue healing and neural regeneration
minimally invasive delivery and providing physical and chemical support for damaged tissue. In this study, an injectable hyaluronic acid (HA) hydrogel was developed based on guest-host interactions between cyclodextrin and adamantane groups. Rheological characterization of the hydrogel confirmed that altering the HA content optimized material properties to match those of endogenous brain tissue. In addition, the shear-thinning and self-healing properties necessary for the injectability of the hydrogel were verified.
toxicity testing
a lactate dehydrogenase (LDH) assay with primary mouse astrocytes established the biocompatibility of the hydrogel prior to
studies. Importantly, intracortical injections of the hydrogel in mice elicited a modest inflammatory response comparable to a control polymer thereby indicating that this HA hydrogel may serve as a platform for future neural tissue engineering systems.
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Details
- Title
- A guest-host hydrogel for neural tissue engineering applications
- Creators
- Gregory Jensen - Arizona State UniversityAlexis Williams - Arizona State UniversityJuhi Khandelwal - Arizona State UniversityAlexander R Osidach - Drexel UniversityChristopher B Rodell - Drexel UniversityJulianne L Holloway - Arizona State UniversitySarah E Stabenfeldt (Corresponding Author) - Arizona State University
- Publication Details
- Journal of materials chemistry. B, Materials for biology and medicine, Forthcoming
- Publisher
- Royal Society of Chemistry
- Number of pages
- 15
- Grant note
- National Institute of Neurological Disorders and Stroke: R01NS116657 Arizona Biomedical Research Commission: ADHS18-198843 Arizona Alzheimer's Consortium: Unassigned National Institute of General Medical Sciences: R35GM147184 Office of Postsecondary Education: P200A240131
We acknowledge the following funding sources: National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS, R01NS116657, S. E. S.) and National Institute of General Medical Sciences (NIGMS, R35GM147184, C. B. R.), Arizona Biomedical Research Centre (ADHS18-198843, S. E. S.), Arizona Alzheimer's Consortium (S. E. S.), Department of Education Graduate Assistance in Areas of National Need Fellowship (GAANN, P200A240131, A. R. O.), and Achievement Rewards for College Scientists (ARCS, G. J.). The authors would like to thank Irene Zhang and Shannon Grassi for development of the injection force testing system, as well as Amanda Witten and Crystal Willingham for training on tissue cryosectioning. We also acknowledge the ASU Core Facilities for training and access to the NMR equipment, plate reader, cryostat, and slide scanner.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001792912200001
- Scopus ID
- 2-s2.0-105041846719
- Other Identifier
- 991022192032304721