Journal article
A highly conserved region upstream of the fibronectin alternative exon EIIIA 3′ splice site interacts with cell-type-specific nuclear proteins
Biochimica et biophysica acta. Gene structure and expression, v 1395(2)
1998
PMID: 9473640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sequencing of chicken fibronectin genomic DNA and interspecies sequence comparisons reveal a highly conserved region upstream of the alternatively spliced exon EIIIA. UV-crosslinking of RNAs corresponding to this region from the chicken and rat genes with HeLa nuclear extract demonstrates that both RNAs interact with similar proteins. However, both RNAs crosslink to a 70
kDa protein present in nuclear extracts from cells and tissues that include exon EIIIA, but not in extracts from tissues that exclude the exon. This protein represents a candidate cell-type-specific factor involved in exon EIIIA inclusion.
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Details
- Title
- A highly conserved region upstream of the fibronectin alternative exon EIIIA 3′ splice site interacts with cell-type-specific nuclear proteins
- Creators
- Pamela A Norton - Department of Medicine, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USATatyana Uporova - Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USAVickie D Bennett - Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
- Publication Details
- Biochimica et biophysica acta. Gene structure and expression, v 1395(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000071925000004
- Scopus ID
- 2-s2.0-0032554025
- Other Identifier
- 991014878083704721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics