Journal article
A highly enantioselective synthesis of (R)-(-)-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol. A key intermediate in the synthesis of anthracyclinones
Tetrahedron letters, v 32(7), pp 867-870
1991
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
AB-Synthon (R)-(−)-
5, a key intermediate in the asymmetric synthesis of anthracyclinones
3 and
4 is prepared in 35% overall yield and > 95% ee. The key step involves hydroxylation of the potassium enolate of
7 using N-sulfonyloxaziridine (−)-
6c.
AB-Synthon (R)-
5, a key intermediate in the synthesis of the antitumor anthracyclinones, was prepared in 35% overall yield in > 95% ee via the enantioselective hydroxylation of the β-ketoester potassium enolate using N-sulfonyloxazridine (-)-
6
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Details
- Title
- A highly enantioselective synthesis of (R)-(-)-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol. A key intermediate in the synthesis of anthracyclinones
- Creators
- Franklin A. Davis - Drexel UniversityAnil Kumar - Drexel UniversityBang-Chi Chen - Drexel University
- Publication Details
- Tetrahedron letters, v 32(7), pp 867-870
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1991EX89200010
- Scopus ID
- 2-s2.0-0026078036
- Other Identifier
- 991019173825104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Organic