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Journal article
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
Nature genetics, v 41(11), pp 1228-1233
01 Nov 2009
PMID: 19838195
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Abstract
Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P <= 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.
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Details
- Title
- A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
- Creators
- Vesela Gateva - GenentechJohanna K. Sandling - Uppsala UniversityGeoff Hom - GenentechKimberly E. Taylor - University of California, San FranciscoSharon A. Chung - University of California, San FranciscoXin Sun - GenentechWard Ortmann - GenentechRoman Kosoy - University of California, DavisRicardo C. Ferreira - GenentechGunnel Nordmark - Uppsala UniversityIva Gunnarsson - Karolinska InstitutetElisabet Svenungsson - Karolinska InstitutetLeonid Padyukov - Karolinska InstitutetGunnar Sturfelt - Lund UniversityAndreas Jonsen - Lund UniversityAnders A. Bengtsson - Lund UniversitySolbritt Rantapaa-Dahlqvist - Umeå UniversityEmily C. Baechler - University of MinnesotaElizabeth E. Brown - University of Alabama at BirminghamGraciela S. Alarcon - University of Alabama at BirminghamJeffrey C. Edberg - University of Alabama at BirminghamRosalind Ramsey-Goldman - Northwestern UniversityGerald McGwin - University of Alabama at BirminghamJohn D. Reveille - The University of Texas Health Science Center at HoustonLuis M. Vila - University of Puerto Rico, Medical Sciences CampusRobert P. Kimberly - University of Alabama at BirminghamSusan Manzi - University of PittsburghMichelle A. Petri - Johns Hopkins UniversityAnnette Lee - Northwell HealthPeter K. Gregersen - Northwell HealthMichael F. Seldin - University of California, DavisLars Ronnblom - Uppsala UniversityLindsey A. Criswell - University of California, San FranciscoAnn-Christine Syvanen - Uppsala UniversityTimothy W. Behrens - GenentechRobert R. Graham - Genentech
- Publication Details
- Nature genetics, v 41(11), pp 1228-1233
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- R01 AR044804-01A1; R01 AR043727; R01 AR44804; K24 AR002175; R01 AR043727-03; K24 AR02175; K24 AR002175-01A1; R01 AR43727 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) K24AR002175 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) UL1RR025005 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01 RR000079; UL1 RR025005-01; UL1RR025005; 5 M01 RR-00079; UL1 RR025005; UL1 RR025741 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000271247600016
- Scopus ID
- 2-s2.0-70350650472
- Other Identifier
- 991021934005504721
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- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity