Journal article
A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
Psychiatry research, v 70(3), pp 131-143
1997
PMID: 9211575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A sex chromosome locus for psychosis has been considered on the basis of some sex differences in genetic risk and expression of illness, and an association with X-chromosome anomalies. Previous molecular genetic studies produced weak evidence for linkage of schizophrenia to the proximal short arm of the X-chromosome, while some other regions were not ruled out. Here we report an attempt to expand the Xp findings in: (i) a multicenter collaboration focusing on 92 families with a maternal pattern of inheritance (Study I.); and (ii) an independent sample of 34 families unselected for parental mode of transmission (Study II.). In the multicenter study, a parametric analysis resulted in positive lod scores (highest of 1.97 for dominant and 1.19 for recessive inheritance at a theta of 0.20) for locus
DXS7, with scores below 0.50 for other markers in this region (
MAOB,
DXS228, and
ARAF1). Significant allele sharing among affected sibling pairs was present at
DXS7. In the second study, positive lod scores were observed at
MAOB (highest of 2.16 at a theta of 0.05 for dominant and 1.64 at a theta of 0.00 for recessive models) and
ALAS2 (the highest of 1.36 at a theta of 0.05 for a recessive model), with significant allele sharing (
P=0.003 and 0.01, respectively) at these two loci. These five markers are mapped within a small region of Xp11. Thus, although substantial regions of the X-chromosome have been investigated without evidence for linkage being found, a locus predisposing to schizophrenia in the proximal short arm of the X-chromosome is not excluded.
© 1997 Elsevier Science Ireland Ltd.
Metrics
Details
- Title
- A linkage study of schizophrenia to markers within Xp11 near the MAOB gene
- Creators
- Janine Dann - Warneford HospitalLynn E DeLisi - Stony Brook UniversityMarcella Devoto - Rockefeller UniversitySteven Laval - Warneford HospitalDerek J Nancarrow - Park Centre for Mental HealthGail Shields - Stony Brook UniversityAngela Smith - Stony Brook UniversityJosephine Loftus - Warneford HospitalPaula Peterson - Stony Brook UniversityAntonio Vita - University of MilanMargherita Comazzi - University of MilanGiordano Invernizzi - University of MilanDouglas F Levinson - Allegheny University of the Health SciencesDieter Wildenauer - University of BonnBryan J Mowry - Park Centre for Mental HealthDavid Collier - The Institute of Psychiatry, London, UKJohn Powell - The Institute of Psychiatry, London, UKRaymond R Crowe - University of IowaNancy C Andreasen - University of IowaJeremy M Silverman - Icahn School of Medicine at Mount SinaiRichard C Mohs - Icahn School of Medicine at Mount SinaiRobin M Murray - The Institute of Psychiatry, London, UKMarilyn K Walters - QIMR Berghofer Medical Research InstituteDavid P Lennon - Park Centre for Mental HealthNicholas K Hayward - QIMR Berghofer Medical Research InstituteMargot Albus - University of BonnBernard Lerer - Department of Psychiatry, University Medical Center, Jerusalem, IsraelWolfgang Maier - University of BonnTimothy J Crow - Warneford HospitalAshley C Smith - Photography
- Publication Details
- Psychiatry research, v 70(3), pp 131-143
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Photography
- Web of Science ID
- WOS:A1997XG32600001
- Scopus ID
- 2-s2.0-0030755699
- Other Identifier
- 991019168801704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry