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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A mechanical argument for the differential performance of coronary artery grafts
Journal of the mechanical behavior of biomedical materials, v 54, pp 93-105
01 Feb 2016
PMID: 26437296
Abstract
Coronary artery bypass grafting (CABG) acutely disturbs the homeostatic state of the transplanted vessel making retention of graft patency dependent on chronic remodeling processes. The time course and extent to which remodeling restores vessel homeostasis will depend, in part, on the nature and magnitude of the mechanical disturbances induced upon transplantation. In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD) and analogs of common autografts, including the internal thoracic artery (ITA), radial artery (RA), great saphenous vein (GSV) and lateral saphenous vein (LSV). Experimental data were used to quantify the parameters of a structure-based constitutive model enabling prediction of the acute vessel mechanical response pre-transplantation and under coronary loading conditions. A novel metric Ξ was developed to quantify mechanical differences between each graft vessel in situ and the LAD in situ, while a second metric Ω compares the graft vessels in situ to their state under coronary loading. The relative values of these metrics among candidate autograft sources are consistent with vessel-specific variations in CABG clinical success rates with the ITA as the superior and GSV the inferior graft choices based on mechanical performance. This approach can be used to evaluate other candidate tissues for grafting or to aid in the development of synthetic and tissue engineered alternatives.
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Details
- Title
- A mechanical argument for the differential performance of coronary artery grafts
- Creators
- David A. Prim - University of South CarolinaBoran Zhou - University of South CarolinaAdam Hartstone-Rose - University of South CarolinaMark J. Uline - University of South CarolinaTarek Shazly - University of South CarolinaJohn F. Eberth - University of South Carolina
- Publication Details
- Journal of the mechanical behavior of biomedical materials, v 54, pp 93-105
- Publisher
- Elsevier
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000368950300009
- Scopus ID
- 2-s2.0-84943547251
- Other Identifier
- 991021902593104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials