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Journal article
A mechanism for improved talc pleurodesis via foam delivery
Drug delivery, v 28(1), pp 733-740
01 Jan 2021
PMID: 33827326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Talcum powder is recognized as the leading drug for pleurodesis, a treatment of choice for malignant pleural effusions. Recently, it was shown that hydrogel foam delivery systems significantly enhanced the number of adhesions between the chest wall and the lung in a New Zealand rabbit model due to the sol-gel transition. However, many questions still remain regarding the cause of improved efficacy, such as: (1) Would only hydrogel foams improve the efficacy of talc pleurodesis? (2) Is it possible to achieve the same efficacy of hydrogels using non-hydrogel foams? 3) What are the physicochemical properties that can be correlated to the efficacy of talc pleurodesis? In this study, we use non-hydrogel foam formulations to determine the efficacy of pleurodesis. Foam stability and rheology of the formulations were correlated to adhesion formation. The results clearly suggest a correlation of pleurodesis efficacy to the viscosity and modulus of the foam delivery system.
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Details
- Title
- A mechanism for improved talc pleurodesis via foam delivery
- Creators
- T. A. Lima - Drexel UniversityR. A. Coler - Drexel UniversityG. W. Laub - Drexel UniversityS. Sexton - Roswell Park Cancer InstituteL. Curtin - Roswell Park Cancer InstituteK. M. Laub - Princeton UniversityN. J. Alvarez - Drexel University
- Publication Details
- Drug delivery, v 28(1), pp 733-740
- Publisher
- Taylor & Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000637965100001
- Scopus ID
- 2-s2.0-85103997413
- Other Identifier
- 991019167974804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy