Journal article
A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites
Molecular and biochemical parasitology, v 133(1), pp 15-26
2004
PMID: 14668008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pore-forming proteins are employed by many pathogens to achieve successful host colonization. Intracellular pathogens use pore-forming proteins to invade host cells, survive within and productively interact with host cells, and finally egress from host cells to infect new ones. The malaria-causing parasites of the genus
Plasmodium evolved a number of life cycle stages that enter and replicate in distinct cell types within the mosquito vector and vertebrate host. Despite the fact that interaction with host-cell membranes is a central theme in the
Plasmodium life cycle, little is known about parasite proteins that mediate such interactions. We identified a family of five related genes in the genome of the rodent malaria parasite
Plasmodium yoelii encoding secreted proteins all bearing a single membrane-attack complex/perforin (MACPF)-like domain. Each protein is highly conserved among
Plasmodium species. Gene expression analysis in
P. yoelii and the human malaria parasite
Plasmodium falciparum indicated that the family is not expressed in the parasites blood stages. However, one of the genes was significantly expressed in
P. yoelii sporozoites, the stage transmitted by mosquito bite. The protein localized to the micronemes of sporozoites, organelles of the secretory invasion apparatus intimately involved in host-cell infection. MACPF-like proteins may play important roles in parasite interactions with the mosquito vector and transmission to the vertebrate host.
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Details
- Title
- A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites
- Creators
- Karine Kaiser - Department of Pathology, Michael Heidelberger Division, New York University School of Medicine, New York, NY 10016, USANelly Camargo - Department of Pathology, Michael Heidelberger Division, New York University School of Medicine, New York, NY 10016, USAIsabelle Coppens - Infectious Diseases Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8022, USAJoanne M Morrisey - Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USAAkhil B Vaidya - Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USAStefan H.I Kappe - Department of Pathology, Michael Heidelberger Division, New York University School of Medicine, New York, NY 10016, USA
- Publication Details
- Molecular and biochemical parasitology, v 133(1), pp 15-26
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000187807000002
- Scopus ID
- 2-s2.0-0344665653
- Other Identifier
- 991014877764504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Parasitology