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A meta-analysis on the prevalence of Charcot-Marie-Tooth disease and related inherited peripheral neuropathies
Journal article   Peer reviewed

A meta-analysis on the prevalence of Charcot-Marie-Tooth disease and related inherited peripheral neuropathies

Miaomiao Ma, Yao Li, Shimiao Dai, Ming Chu, Litao Sun, Longjian Liu and Ji-Chang Zhou
Journal of neurology, v 270(5), pp 2468-2482
May 2023
DOI: https://doi.org/10.1007/s00415-023-11559-8
PMID: 36631678
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Charcot-Marie-Tooth Disease - epidemiology Charcot-Marie-Tooth Disease - genetics Data Management Female Humans Male Prevalence Europe
Background Charcot–Marie–Tooth disease and related inherited peripheral neuropathies (CMT&RIPNs) brings great suffering and heavy burden to patients, but its global prevalence rates have not been well described. Methods We searched major English and Chinese databases for studies reporting the prevalence of CMT&RIPNs from the establishment of the databases to September 26, 2022. Based on the age, gender, study design, study region, and disease subtype, the included studies were correspondingly synthesized for meta-analyses on the overall prevalence and/or the subgroup analyses by using pool arcsine transformed proportions in the random-effects model. Results Of the finally included 31 studies, 21 studied the whole age population and various types of CMT&RIPNs, and the others reported specific disease subtype(s) or adult or non-adult populations. The pooled prevalence was 17.69/100,000 (95% CI 12.32–24.33) for the whole age population and significantly higher for CMT1 [10.61/100,000 (95% CI 7.06–14.64)] than for other subtypes (P’ < 0.001). Without statistical significance, the prevalence seemed higher in those aged ≥ 16 or 18 years (21.02/100,000) than in those aged < 16 years (16.13/100,000), in males (22.50/100,000) than in females (17.95/100,000), and in Northern Europe (30.97/100,000) than in other regions. Conclusion CMT&RIPNs are relatively more prevalent as CMT1 in the disease subtypes, and probably prevalent in older ages, males, and Northern Europe. More studies on the epidemiological characteristics of CMT&RIPNs with well-defined diagnosis criteria are needed to improve the prevalence evaluation and to arouse more attention to health care support.

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Web of Science research areas
Clinical Neurology
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