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A microfabricated quantum dot-linked immuno-diagnostic assay (μQLIDA) with an electrohydrodynamic mixing element
Journal article   Peer reviewed

A microfabricated quantum dot-linked immuno-diagnostic assay (μQLIDA) with an electrohydrodynamic mixing element

Chengjie Yu, Gi-Beum Kim, Peter M. Clark, Leonid Zubkov, Elisabeth S. Papazoglou and Moses Noh
Sensors and actuators. B, Chemical, v 209, pp 722-728
31 Mar 2015
DOI: https://doi.org/10.1016/j.snb.2014.12.033
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

AC electrothermal flow Biosensor Microfabrication, PMMA Microfluidic Quantum dots
We present a microfabricated quantum dot-linked immuno-diagnostic assay (μQLIDA) biosensor with an embedded mixing element. We adapted our previous capillary-based system into a microfabricated planar microchannel, which has been integrated with an active, electrothermal mixing component. With the active mixing element, the detection time was significantly reduced from about 3.5h to 30min in a case study of detecting myeloperoxidase (MPO). MPO is an inflammatory biomarker that is over-expressed in inflammatory conditions including inflammatory bowel disease and cardiovascular disease. The μQLIDA biosensor presented here is a low-cost, rapid immunofluorescence sensor that can detect nanomolar concentrations of MPO, with a working volume of 2μl.

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9 citations in Web of Science
14 citations in Scopus

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Chemistry, Analytical
Electrochemistry
Instruments & Instrumentation
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