Journal article
A microfluidic system for saliva-based detection of infectious diseases
Annals of the New York Academy of Sciences, v 1098(1), pp 429-436
Mar 2007
PMID: 17435147
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A "lab-on-a-chip" system for detecting bacterial pathogens in oral fluid samples is described. The system comprises: (1) an oral fluid sample collector; (2) a disposable, plastic microfluidic cassette ("chip") for sample processing including immunochromatographic assay with a nitrocellulose lateral flow strip; (3) a platform that controls the cassette operation by providing metered quantities of reagents, temperature regulation, valve actuation; and (4) a laser scanner to interrogate the lateral flow strip. The microfluidic chip hosts a fluidic network for cell lysis, nucleic acid extraction and isolation, PCR, and labeling of the PCR product with bioconjugated, upconverting phosphor particles for detection on the lateral flow strip.
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Details
- Title
- A microfluidic system for saliva-based detection of infectious diseases
- Creators
- Zongyuan Chen - University of Pennsylvania School of Engineering and Applied Science, Philadelphia, Pennsylvania, USAMichael G MaukJing WangWilliam R AbramsPaul L A M CorstjensR Sam NiedbalaDaniel MalamudHaim H Bau
- Publication Details
- Annals of the New York Academy of Sciences, v 1098(1), pp 429-436
- Publisher
- United States
- Grant note
- UO1DE0114964 / NIDCR NIH HHS UO1DE017855 / NIDCR NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Engineering Technology
- Web of Science ID
- WOS:000246091500030
- Scopus ID
- 2-s2.0-34248168128
- Other Identifier
- 991014877755504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Dentistry, Oral Surgery & Medicine
- Medical Laboratory Technology