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Journal article
A model study of 3-dimensional localization of breast tumors using piezoelectric fingers of different probe sizes
Review of scientific instruments, v 90(1), pp 015006-015006
01 Jan 2019
PMID: 30709230
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mammography is the only Food and Drug Administration approved breast cancer screening
method. The drawback of the tumor image in a mammogram is the lack of tumor depth
information as it is only a 2-dimensional projection of a 3-dimensional (3D) tumor. In
this work, we investigated 3D tumor imaging by assessing tumor depth information using a
set of piezoelectric fingers (PEFs) with different probe sizes which were known to be
capable of eliciting tissue elastic responses to different depths and tested it on model
tumor tissues consisted of gelatin with suspended clay inclusions. The locations of the
top and bottom surfaces of an inclusion were resolved by solving a simple spring model
using the elastic measurements of the PEFs of different probe sizes as the input. The
lateral sizes of an inclusion were determined as the full width at half maximum of the
Gaussian fit to the measured lateral tumor elastic modulus profile. The obtained lateral
inclusion sizes were in close agreement with the actual values, and the deduced depth
profiles of an inclusion also agreed with the actual depth profiles so long as the bottom
surface of the inclusion was within the depth sensitivity of the PEF with the largest
probe size. This work offers a simple non-invasive method to predict the extent of a tumor
in all 3 dimensions. The method is also non-radioactive.
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Details
- Title
- A model study of 3-dimensional localization of breast tumors using piezoelectric fingers of different probe sizes
- Creators
- Xin Xu - Drexel UniversityWei-Heng Shih - Drexel UniversityWan Y. Shih - Drexel University
- Publication Details
- Review of scientific instruments, v 90(1), pp 015006-015006
- Publisher
- American Institute of Physics
- Grant note
- ; ; 1R41AI112224; 1R41AI120445 / ; ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000457411800052
- Scopus ID
- 2-s2.0-85060620949
- Other Identifier
- 991019167343004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Instruments & Instrumentation
- Physics, Applied