Journal article
A molecular view of DNA-conjugated nanoparticle association energies
Soft matter, v 11(10), pp 1919-1929
14 Mar 2015
PMID: 25611690
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanoparticles functionalized with short sequences of DNA represent a promising platform for customizable self assembly. Though much recent research has focused on the phase behavior and assembly of these structures, little has been done to precisely characterize the pairwise interaction between particles. Here we present a detailed calculation of the association between DNA-nanoparticle conjugates using 3SPN. 2, a coarse-grained model of DNA that accounts for molecular structure and base-pairing. We compare our results to those obtained experimentally using mm sized particles and analyze the free energy surfaces that characterize interparticle hybridization. Next, we study the importance of three-body effects and their impact on particle association and melting. Lastly, we explore the observation by Park et al. [Nature, 451, 553 (2008)] that DNA-nanoparticle crystallization can be inhibited by the deletion of a single nucleotide. Using our model, we suggest that the role of this nucleotide is to disrupt frustration.
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Details
- Title
- A molecular view of DNA-conjugated nanoparticle association energies
- Creators
- Joshua P. Lequieu - University of ChicagoDaniel M. Hinckley - University of Wisconsin–MadisonJuan J. de Pablo - University of ChicagoArgonne National Lab. (ANL), Argonne, IL (United States)
- Publication Details
- Soft matter, v 11(10), pp 1919-1929
- Publisher
- Royal Soc Chemistry
- Number of pages
- 11
- Grant note
- NSF-supported Nansocale Science and Engineering Center (NSEC) DGE-1256259 / National Science Foundation; National Science Foundation (NSF) NIST through the Center for Hierarchical Materials Assembly (CHiMaD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000350679300007
- Scopus ID
- 2-s2.0-84923886679
- Other Identifier
- 991020950550504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Physics, Multidisciplinary
- Polymer Science