Journal article
A multicenter, prospective, randomized, comparative evaluation of dual- versus triple-lumen catheters for hemodialysis and apheresis in 485 patients
American journal of kidney diseases, v 42(2), pp 315-324
Aug 2003
PMID: 12900814
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study is to compare a new temporary triple-lumen catheter (TLC) for dialysis that has a third lumen devoted to fluid and medication administration or blood sampling with a marketed dual-lumen catheter (DLC).
Four hundred eighty-five patients referred for acute hemodialysis or apheresis were randomly assigned to either a TLC or DLC in a multicenter, prospective, randomized trial.
Analysis of blood flow rates was completed on 464 patients (228 patients, DLC; 236 patients, TLC) with a total of 1,681 hemodialysis (808 treatments, DLC; 873 treatments, TLC) and 82 apheresis treatments (37 treatments, DLC; 45 treatments, TLC). During hemodialysis, a median achieved flow rate (AFR) of 267 mL/min was realized for both groups (P = 0.58). During apheresis, a median AFR of 72.5 mL/min (range, 50 to 150 mL/min) was achieved in the DLC group, and 87 mL/min (range, 60 to 150 mL/min), in the TLC group (P = 0.14). Three hundred ninety-three patients (193 patients, DLC; 200 patients, TLC) had blood and catheter tip cultures performed on removal, and catheter-related bloodstream infection (CRBSI) status was determined. Thirty-one patients (7.9%) had a CRBSI: 16 patients (8.3%), DLC; and 15 patients (7.5%), TLC (P= 0.77). Incidence densities of CRBSI were 12.4/1,000 DLC-days and 10.2/1,000 TLC-days (P = 0.59). The CRBSI incidence of 18.2/1,000 catheter-days for femoral sites was significantly greater than the 7/1,000 catheter-days for jugular sites (P = 0.02) and 6.6/1,000 catheter-days for combined jugular and subclavian sites (P = 0.01). In multivariate analysis, antibiotic use was the only factor related to CRBSI (odds ratio, 0.30; 95% confidence interval, 0.12 to 0.76). There were no statistically significant differences in rates of other complications between the 2 catheters.
Results show that the new TLC is similar to the marketed DLC.
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Details
- Title
- A multicenter, prospective, randomized, comparative evaluation of dual- versus triple-lumen catheters for hemodialysis and apheresis in 485 patients
- Creators
- Gabriel Contreras - University of MiamiPing-Yu Liu - Fred Hutchinson Cancer Research CenterLawrence Elzinga - North West Renal Clinic, Portland, OR, USAMichael S Anger - University of Colorado HealthJean Lee - Drexel UniversityNurian Robert - Jackson Memorial HospitalRobert Chvala - Allegheny CollegeRonald L Mars - University of Florida Health Science CenterThomas Vesely - Washington University in St. LouisTim E Taber - Methodist HospitalDouglas Shemin - Rhode Island HospitalRandy Shafritz - University of Medicine and Dentistry New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USAJoseph Pulliam - North West Renal Clinic, Portland, OR, USAJinwook Lee - Decision Sciences (and Management Information Systems)
- Publication Details
- American journal of kidney diseases, v 42(2), pp 315-324
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); Nephrology (and Hypertension)
- Web of Science ID
- WOS:000184557300014
- Scopus ID
- 2-s2.0-10744222681
- Other Identifier
- 991019168979004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology