Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
A neuronal network of mitochondrial dynamics regulates metastasis
Nature communications, v 7(1), pp 13730-13730
19 Dec 2016
PMID: 27991488
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the speed and distance travelled by individual mitochondria, suppresses organelle dynamics, and blocks chemotaxis and metastasis, in vivo. Tumour progression in humans is associated with downregulation or loss of SNPH, which correlates with shortened patient survival, increased mitochondrial trafficking to the cortical cytoskeleton, greater membrane dynamics and heightened cell invasion. Therefore, a SNPH network regulates metastatic competence and may provide a therapeutic target in cancer.
Metrics
Details
- Title
- A neuronal network of mitochondrial dynamics regulates metastasis
- Creators
- M. Cecilia Caino - The Wistar InstituteJae Ho Seo - The Wistar InstituteAngeline Aguinaldo - Drexel UniversityEric Wait - Drexel UniversityKelly G. Bryant - The Wistar InstituteAndrew V. Kossenkov - The Wistar InstituteJames E. Hayden - The Wistar InstituteValentina Vaira - University of MilanAnnamaria Morotti - University of MilanStefano Ferrero - University of MilanSilvano Bosari - University of MilanDmitry I. Gabrilovich - The Wistar InstituteLucia R. Languino - Thomas Jefferson UniversityAndrew R. Cohen - Drexel UniversityDario C. Altieri - The Wistar Institute
- Publication Details
- Nature communications, v 7(1), pp 13730-13730
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- P01 CA140043; R01 CA78810; CA190027; R01 CA089720; R01 NS076709; F32 CA177018; T32 CA009171 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Doctorate School of Molecular and Translational Medicine at the University of Milan R01NS076709 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Prostate Cancer Foundation (PCF) W81XWH-13-1-0193 / Office of the Assistant Secretary of Defense for Health Affairs through the Prostate Cancer Research Program GR2011-02351626 / Italian Minister of Health CA010815 / Cancer Center Support Grant (CCSG) R01CA078810 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000389878800001
- Scopus ID
- 2-s2.0-85006835178
- Other Identifier
- 991019168167604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology