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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A new class of biological materials: Cell membrane-derived hydrogel scaffolds
Biomaterials, v 197
Mar 2019
PMID: 30669015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Biological materials are superior to synthetic biomaterials in biocompatibility and active interactions with cells. Here, a new class of biological materials, cell membrane-derived hydrogel scaffolds are reported for harnessing these advantages. To form macroporous scaffolds, vesicles derived from red blood cell membranes (RBCMs) are chemically crosslinked via cryogelation. The RBCM scaffolds with a pore size of around 70 μm are soft and injectable. Highly biocompatible scaffolds are typically made of superhydrophilic polymers and lack the ability to encapsulate and release hydrophobic drugs in a controlled manner. However, hydrophobic molecules can be efficiently encapsulated inside RBCM scaffolds and be sustainedly released. RBCM scaffolds show low neutrophil infiltration after subcutaneous injection in mice, and a significantly higher number of infiltrated macrophages than methacrylate alginate (MA-alginate) scaffolds. According to gene expression and surface markers, these macrophages have an M2-like phenotype, which is anti-inflammatory and immune suppressive. There are also higher percentages of macrophages presenting immunosuppressive PD-L1 in RBCM-scaffolds than in MA-alginate scaffolds. Interestingly, the concentrations of anti-inflammatory cytokine, IL-10 in both types of scaffolds are higher than those in normal organ tissues. This study sheds light on cell membrane-derived hydrogels, which can actively modulate cells in unique ways unavailable to existing hydrogel scaffolds.
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Details
- Title
- A new class of biological materials: Cell membrane-derived hydrogel scaffolds
- Creators
- Zhiyuan Fan - Drexel UniversityJunjie Deng - Drexel UniversityPeter Y. Li - Drexel UniversityDaphney R. Chery - Drexel UniversityYunfei Su - Chinese Academy of SciencesPu Zhu - Drexel UniversityTaku Kambayashi - University of PennsylvaniaElizabeth P. Blankenhorn - Drexel UniversityLin Han - Drexel UniversityHao Cheng - Drexel University
- Publication Details
- Biomaterials, v 197
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000459363800021
- Scopus ID
- 2-s2.0-85060921760
- Other Identifier
- 991019168268204721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials