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A new online monitoring method for water-in-oil droplet based microfluidic devices
Journal article   Open access   Peer reviewed

A new online monitoring method for water-in-oil droplet based microfluidic devices

Yuchen He, Yu He, Yandan Jiang, Tao Zhang, Haifeng Ji, Baoliang Wang, Zhiyao Huang and Manuchehr Soleimani
IEEE sensors journal, pp 1-1
2022
url
https://doi.org/10.1109/jsen.2022.3181998View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Capacitance contactless impedance detection Couplings dispersed phase holdup droplet length droplet monitoring Electrodes Impedance microfluidic Microfluidics Monitoring Sensors
The online water-in-oil (w/o) droplet monitoring is essential for the uniformity of the droplet based microfluidic devices. In this work, a contactless impedance detection (CID) method for online w/o droplet monitoring in microfluidic devices is proposed. In the proposed method, a new CID sensor, which can work at low working frequency and overcome the unfavorable influence of coupling capacitance, is developed to obtain the impedance information of the w/o droplet. Based on the obtained impedance information, measurement models are established to realize online measurement of drop length and dispersed phase holdup. Then the coefficients of variation (CVs) of the two measured parameters are calculated to evaluate the uniformity of the droplets for online monitoring. Online monitoring experiments of w/o droplet were carried out in a microfluidic device with a 500 μm × 500 μm microchannel. The experimental results verify the effectiveness of the proposed droplet monitoring method. The developed CID sensor can realize impedance measurement at a working frequency lower than 50kHz. The drop length and dispersed phase holdup are useful parameters for online monitoring of droplets. With the established measurement models, the maximum relative error of droplet length measurement is less than 10% in the droplet length range of 1.5mm-3.5mm. And the maximum error of dispersed phase holdup measurement is less than 5% in the dispersed phase holdup range of 0.20-0.67.

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4 citations in Scopus

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Web of Science research areas
Engineering, Electrical & Electronic
Instruments & Instrumentation
Physics, Applied
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