Journal article
A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding by dynorphin-related peptides
Neuropeptides (Edinburgh), v 15(3), pp 133-137
Mar 1990
PMID: 1979153
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-LysNH2; SK&F 110679) is a hexapeptide that specifically releases growth hormone. Although derived from methionine enkephalin, 3H-SK&F 110679 binding profiles suggest that it retains little mu or delta opioid activity. In the present study, dynorphin A was a potent inhibitor of SK&F 110679 binding. However, detailed structure-activity studies using dynorphin-related compounds suggest that the interaction between SK&F 110679 and dynorphin was non-opioid in nature. The non-opioid peptide des-Tyr-dynorphin was virtually as potent an inhibitor of 3H-SK&F 110679 binding as the intact dynorphin peptide. Additionally, the non-peptide, kappa selective ligand U-50,488 was a very weak inhibitor of 3H-SK&F 110679 binding. Since dynorphin but not U-50,488 has been reported to release growth hormone, the present results suggest that a non-opioid dynorphin site participates in SK&F 110679's growth hormone releasing action.
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Details
- Title
- A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding by dynorphin-related peptides
- Creators
- E E Codd - SpringhouseV J Aloyo - Drexel UniversityR F Walker - Drexel University
- Publication Details
- Neuropeptides (Edinburgh), v 15(3), pp 133-137
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1990CR34900003
- Scopus ID
- 2-s2.0-0025008929
- Other Identifier
- 991019184315504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Neurosciences