Journal article
A novel behavioral model that discriminates between 5-HT 2A and 5-HT 2C receptor activation
Pharmacology, biochemistry and behavior, v 72(1), pp 371-378
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
2,5-Dimethoxy-4-iodoamphetamine (DOI), a serotonin (5-HT)
2A/2C receptor agonist, elicits shaking behaviors in rodents, which have been reliably quantified as behavioral correlates of 5-HT
2A receptor activation. Such studies are lacking in the rabbit. As part of our research examining the role of the 5-HT
2 receptor in rabbits, we analyzed the behavioral effects of systemically administered DOI in rabbits. DOI (0.01–3 μmol/kg) or vehicle was injected, and two distinct behaviors, head bobs (vertical head movements) and body shakes (wet dog shakes), were counted for 90 min following the injection. DOI dose-dependently increased the number of head bobs and body shakes. The selective 5-HT
2A receptor antagonist ketanserin (1–3 μmol/kg), 1 h before DOI (0.3 μmol/kg) challenge, significantly attenuated head bobs, but not body shakes. In contrast, the selective 5-HT
2C receptor antagonists SDZ SER 082 (1–3 μmol/kg) and SB 206553 (1 μmol/kg) 30 min before challenge, significantly reduced body shakes but not head bobs produced by the same dose of DOI. This study establishes that, in rabbits, DOI mediates head bobs via 5-HT
2A receptors and body shakes via 5-HT
2C receptors. Thus, the rabbit provides a novel behavioral assay that discriminates between 5-HT
2A and 5-HT
2C receptor activation.
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Details
- Title
- A novel behavioral model that discriminates between 5-HT 2A and 5-HT 2C receptor activation
- Creators
- Kuldip D Dave - Hahnemann University HospitalJohn A Harvey - Hahnemann University HospitalVincent J Aloyo - Hahnemann University Hospital
- Publication Details
- Pharmacology, biochemistry and behavior, v 72(1), pp 371-378
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000177065200047
- Scopus ID
- 2-s2.0-0036202493
- Other Identifier
- 991019167549504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy