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Journal article
A novel binding pocket of cyclin-dependent kinase 2
Proteins, structure, function, and bioinformatics, v 74(1), pp 122-132
01 Jan 2009
PMID: 18615713
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The cyclin-dependent kinase 2 (cdk2) is a serine/threonine protein kinase that plays a key role in the cell cycle control system of all eukaryotic organisms. It has been a much studied drug target for potential anticancer therapy. Most cdk2 inhibitors in clinical development target almost exclusively the catalytic ATP-binding pocket of cdk2. However, several five amino-acid peptide inhibitors that are directed towards a noncatalytic binding pocket of cdk2 are reported here. Upon binding to this new pocket located at the cdk2 and cyclin interface, these peptide inhibitors are found to disrupt the cdk2/cyclin E complex partially and diminish its kinase activity in vitro.
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Details
- Title
- A novel binding pocket of cyclin-dependent kinase 2
- Creators
- Hao Chen - George Washington UniversityRachel Van Duyne - George Washington UniversityNaigong Zhang - George Washington UniversityFatah Kashanchi - George Washington UniversityChen Zeng - George Washington University
- Publication Details
- Proteins, structure, function, and bioinformatics, v 74(1), pp 122-132
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- George Washington University REF, SE AI065236; AI043894 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21AI065236 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) DMR0313129 / NSF; National Science Foundation (NSF) Conrad; United States Agency for International Development (USAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000261757900011
- Scopus ID
- 2-s2.0-58949085676
- Other Identifier
- 991021903124304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics